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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-4-2
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pubmed:abstractText |
Matrix metalloproteinase-3 (MMP3) is implicated in the pathogenesis and progression of atherosclerotic lesions. Previous studies suggested that MMP3 expression is influenced by a polymorphism (known as the 5A/6A polymorphism) in the promoter of the MMP3 gene and that this polymorphism is located within a cis-element that interacts with the transcription factor NFkappaB. In the present study, we sought to investigate whether MMP3 and NFkappaB were co-localized in atherosclerotic lesions and whether NFkappaB had differential effects on the two alleles of the MMP3 5A/6A polymorphism.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e9902
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pubmed:meshHeading |
pubmed-meshheading:20360864-Alleles,
pubmed-meshheading:20360864-Animals,
pubmed-meshheading:20360864-Atherosclerosis,
pubmed-meshheading:20360864-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:20360864-Genes, Dominant,
pubmed-meshheading:20360864-Humans,
pubmed-meshheading:20360864-Immunohistochemistry,
pubmed-meshheading:20360864-Lipopolysaccharides,
pubmed-meshheading:20360864-Matrix Metalloproteinase 3,
pubmed-meshheading:20360864-Mice,
pubmed-meshheading:20360864-Mutation,
pubmed-meshheading:20360864-NF-kappa B,
pubmed-meshheading:20360864-Polymorphism, Genetic,
pubmed-meshheading:20360864-Promoter Regions, Genetic,
pubmed-meshheading:20360864-Quinazolines
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pubmed:year |
2010
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pubmed:articleTitle |
Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaB.
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pubmed:affiliation |
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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