Linked Life Data

2036070

Source:http://linkedlifedata.com/resource/pubmed/id/2036070

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-6-24
pubmed:abstractText
In a randomised, double-blind cross-over study, objective measures were used to compare the effect of a single oral dose of a standard preparation of levodopa-benserazide (Madopar M) with a sustained-release preparation (Madopar HBS) in 9 Parkinsonian patients with 'end of dose deterioration'. The response of patients to an optimised regimen of each preparation was also assessed using a patient diary. In all patients the onset of effect of Madopar HBS following a single dose was delayed compared with Madopar M. The duration of effect of a single dose of Madopar HBS was substantially (38-120%) longer than Madopar M in five patients and the same or shorter in four patients. According to the patients' diaries, six patients noted an increase in 'on' hours while on Madopar HBS. The duration and severity of dyskinesia was similar for the two preparations. Madopar HBS is likely to be useful in some Parkinsonian patients with 'end of dose deterioration'. As the effect of each dose is delayed it is probably best given in combination with standard Madopar.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0004-8291
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-5
pubmed:dateRevised
2009-12-23
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
A comparison of standard Madopar and controlled release Madopar in Parkinson's disease.
pubmed:affiliation
Neurology Unit, Westmead Hospital, NSW, Australia.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't