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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-6-23
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pubmed:abstractText |
Antigen-specific immunotherapy is expected to be an ideal strategy for treating type 1 diabetes (T1D). We investigated the therapeutic efficacy of a peptide in the leader sequence of preproinsulin, which was selected because of its binding affinity to the MHC I-A(g7) molecule. Preproinsulin-1 L7-24 peptide (L7-24) emulsified in Freund's incomplete adjuvant was administered subcutaneously to NOD mice. Administration of L7-24 increased the proportion of regulatory T cells in the spleen. Splenocytes of NOD mice immunized with this peptide secreted IL-4 and IL-10 in response to L7-24. This peptide also significantly prevented the development of diabetes and cured some newly diabetic NOD mice without recurrence. L7-24 peptide, which has a high affinity for pockets of I-A(g7), induced regulatory T cells and showed therapeutic effects. This peptide may provide a new approach for developing antigen-specific immunotherapy for autoimmune diabetes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Concanavalin A,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Foxp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/preproinsulin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1521-7035
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
74-82
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20359955-Amino Acid Sequence,
pubmed-meshheading:20359955-Animals,
pubmed-meshheading:20359955-Autoimmunity,
pubmed-meshheading:20359955-Blood Glucose,
pubmed-meshheading:20359955-Cell Count,
pubmed-meshheading:20359955-Concanavalin A,
pubmed-meshheading:20359955-Diabetes Mellitus, Type 1,
pubmed-meshheading:20359955-Female,
pubmed-meshheading:20359955-Forkhead Transcription Factors,
pubmed-meshheading:20359955-Histocompatibility Antigens Class II,
pubmed-meshheading:20359955-Immunotherapy, Active,
pubmed-meshheading:20359955-Insulin,
pubmed-meshheading:20359955-Interferon-gamma,
pubmed-meshheading:20359955-Interleukin-10,
pubmed-meshheading:20359955-Interleukin-4,
pubmed-meshheading:20359955-Islets of Langerhans,
pubmed-meshheading:20359955-Lymphocyte Activation,
pubmed-meshheading:20359955-Mice,
pubmed-meshheading:20359955-Mice, Inbred NOD,
pubmed-meshheading:20359955-Mice, Knockout,
pubmed-meshheading:20359955-Peptide Fragments,
pubmed-meshheading:20359955-Protein Binding,
pubmed-meshheading:20359955-Protein Precursors,
pubmed-meshheading:20359955-Spleen,
pubmed-meshheading:20359955-T-Lymphocytes,
pubmed-meshheading:20359955-T-Lymphocytes, Regulatory,
pubmed-meshheading:20359955-Th2 Cells,
pubmed-meshheading:20359955-Transforming Growth Factor beta,
pubmed-meshheading:20359955-Vaccination
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pubmed:year |
2010
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pubmed:articleTitle |
Administration of a determinant of preproinsulin can induce regulatory T cells and suppress anti-islet autoimmunity in NOD mice.
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pubmed:affiliation |
Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
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pubmed:publicationType |
Journal Article
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