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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-6-1
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pubmed:abstractText |
The most adequate way to experimentally reproduce the post-prandial lipemia condition appears to be the administration of a standardized oral fat load (OFL) to fasting patients. We studied the effects of a standardized OFL on markers of vascular remodelling in healthy subjects. We enrolled 286 Caucasians aged >or= 18 of either sex. The OFL was given after a 12-h fast. Blood samples were drawn before and 3, 6, 9 and 12h after the fat load. The following parameters were evaluated: body mass index (BMI), blood glucose (BG), systolic blood pressure (SBP), diastolic blood pressure (DBP), lipid profile, nitrites and nitrates, adiponectin (ADP), metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9). High density lipoprotein-cholesterol (HDL-C) decrease was present in subjects after 6h. Triglycerides (Tg) change was observed after 6h. Nitrites/nitrates variation was observed after 6 and 9h during OFL. Adiponectin level was decreased after 6 and 9h during OFL. Both MMP-2 and MMP-9 levels were higher after 6h during OFL. We observed that nitrites/nitrates and ADP significantly decreased and MMP-2 and MMP-9 significantly increased after a standardized OFL. Other studies need to confirm the direct acute effects of post-prandial lipemia on vascular damage.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adiponectin,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrates,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrites,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/adiponectin, human
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1095-9319
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pubmed:author |
pubmed-author:CiceroArrigo F GAF,
pubmed-author:D'AngeloAngelaA,
pubmed-author:DerosaGiuseppeG,
pubmed-author:FerrariIlariaI,
pubmed-author:FogariElenaE,
pubmed-author:GravinaAlessiaA,
pubmed-author:MaffioliPamelaP,
pubmed-author:MereuRobertoR,
pubmed-author:PalumboIlariaI,
pubmed-author:RandazzoSabrinaS,
pubmed-author:SalvadeoSibilla A TSA
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
110-5
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pubmed:meshHeading |
pubmed-meshheading:20359487-Adiponectin,
pubmed-meshheading:20359487-Adult,
pubmed-meshheading:20359487-Biological Markers,
pubmed-meshheading:20359487-Blood Glucose,
pubmed-meshheading:20359487-Cholesterol,
pubmed-meshheading:20359487-Cholesterol, HDL,
pubmed-meshheading:20359487-Cholesterol, LDL,
pubmed-meshheading:20359487-Dietary Fats,
pubmed-meshheading:20359487-Endothelium, Vascular,
pubmed-meshheading:20359487-Female,
pubmed-meshheading:20359487-Humans,
pubmed-meshheading:20359487-Hyperlipidemias,
pubmed-meshheading:20359487-Male,
pubmed-meshheading:20359487-Matrix Metalloproteinase 2,
pubmed-meshheading:20359487-Matrix Metalloproteinase 9,
pubmed-meshheading:20359487-Middle Aged,
pubmed-meshheading:20359487-Nitrates,
pubmed-meshheading:20359487-Nitrites,
pubmed-meshheading:20359487-Postprandial Period,
pubmed-meshheading:20359487-Triglycerides
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pubmed:year |
2010
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pubmed:articleTitle |
Effects of a standardized oral fat load on vascular remodelling markers in healthy subjects.
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pubmed:affiliation |
Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. giuseppe.derosa@unipv.it
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Multicenter Study
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