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rdf:type |
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lifeskim:mentions |
umls-concept:C0026809,
umls-concept:C0062068,
umls-concept:C0242488,
umls-concept:C0389995,
umls-concept:C0599946,
umls-concept:C1335631,
umls-concept:C1412517,
umls-concept:C1423613,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1720675
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pubmed:issue |
4
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pubmed:dateCreated |
2010-4-1
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pubmed:abstractText |
The transendothelial migration of polymorphonuclear leukocytes (PMNs, neutrophils) may be a hallmark of acute lung injury (ALI). The breakdown of the vascular endothelial barrier has likewise been considered to have etiologic linkage in the pathogenesis of ALI. Rho-associated coiled-coil-forming protein kinase (ROCK), a downstream target effector of the small GTP-binding protein Rho, plays a key role in cell adhesion, motility, and contraction mediated by reorganization of the actin cytoskeleton. The aims were to investigate protection by fasudil in lipopolysaccharide (LPS)-induced ALI and the role of ROCK2 in neutrophil transendothelial migration in a murine model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1643-3750
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
BR112-118
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pubmed:dateRevised |
2011-6-14
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pubmed:meshHeading |
pubmed-meshheading:20357711-1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine,
pubmed-meshheading:20357711-Animals,
pubmed-meshheading:20357711-Bronchoalveolar Lavage,
pubmed-meshheading:20357711-Cell Movement,
pubmed-meshheading:20357711-Endothelium, Vascular,
pubmed-meshheading:20357711-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:20357711-Lipopolysaccharides,
pubmed-meshheading:20357711-Lung,
pubmed-meshheading:20357711-Male,
pubmed-meshheading:20357711-Mice,
pubmed-meshheading:20357711-Mice, Inbred C57BL,
pubmed-meshheading:20357711-Neutrophils,
pubmed-meshheading:20357711-Organ Size,
pubmed-meshheading:20357711-Protein Kinase Inhibitors,
pubmed-meshheading:20357711-RNA, Messenger,
pubmed-meshheading:20357711-rho GTP-Binding Proteins,
pubmed-meshheading:20357711-rho-Associated Kinases
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pubmed:year |
2010
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pubmed:articleTitle |
Fasudil attenuates lipopolysaccharide-induced acute lung injury in mice through the Rho/Rho kinase pathway.
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pubmed:affiliation |
Department of Pathophysiology, Institute of Integrated Traditional Chinese and Western Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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