Linked Life Data

20357121

Source:http://linkedlifedata.com/resource/pubmed/id/20357121

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2010-4-1
pubmed:abstractText
Neuroscientists have observed the "birth" of memories, but have not explored how an organism's past experience with materials interacts with the neural mechanisms of episodic memory formation. Using functional neuroimaging, we searched for such an interaction by examining brain activity during memory encoding that predicted participants' subsequent episodic memory for novel and repeated scenes. Memory for both scene types was predicted by a common posterior network in occipital and parietal cortices. Medial temporal memory predictors were modulated by scene repetition: the right anterior hippocampus and right amygdala predicted memory for novel scenes only, whereas posterior hippocampi predicted memory for repeated scenes only. There was also greater functional connectivity between the temporal pole and anterior versus posterior hippocampus, and this link predicted memory for novel but not repeated scenes. In contrast, there was greater functional connectivity between the precuneus and posterior versus anterior hippocampus, and this link predicted memory for repeated but not novel scenes. Together, these results reveal a functional specialization within the hippocampus for the encoding of novel and previously experienced materials, and suggest that the topography of this specialization might be related to local variations in connectivity. Because episodic memory for repeated scenes was superior, our results also support traditional views of encoding emphasizing the role of prior representations, and illuminate one way in which humans use existing memories to help form new ones. In so doing, our results challenge recent novelty-encoding hypotheses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
31
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4707-16
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Past experience modulates the neural mechanisms of episodic memory formation.
pubmed:affiliation
Department of Psychology, University of Toronto, Toronto, Ontario M5S 3G3, Canada. jpoppenk@rotman-baycrest.on.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't