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pubmed:abstractText |
Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population.
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pubmed:affiliation |
Hagedorn Research Institute, Niels Steensens Vej 1, NLD 2.13, 2820 Gentofte, Copenhagen, Denmark.
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