Source:http://linkedlifedata.com/resource/pubmed/id/20354348
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| Predicate | Object |
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| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-3-31
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| pubmed:abstractText |
We attempted to isolate the constituent(s) responsible for the suppressive effect of the juice of shekwasha, a citrus produced in Okinawa Prefecture, on D-galactosamine (GalN)-induced liver injury in rats. Liver injury-suppressive activity, as assessed by plasma alanine aminotransferase and aspartate aminotransferase activities, was found only in the fraction that was extracted with n-hexane when three fractions were added to the diet and fed to rats. Of five compounds isolated from the n-hexane-soluble fraction by silica gel column chromatography, three compounds had liver injury-suppressive effects when five compounds were singly force-fed to rats at a level of 300 mg/kg body wt 4 h before the injection with GalN. The structures of the three active compounds were determined as 3',4',5,6,7,8-hexamethoxyflavanone (citromitin), 4',5,6,7,8-pentamethoxyflavone (tangeretin) and 3',4',5,6,7,8-hexamethoxyflavone (nobiletin), which are known flavonoids mainly existing in citrus. Nobiletin, the most important compound in the n-hexane-soluble fraction, also had suppressive effects on liver injuries induced by carbon tetrachloride, acetaminophen and GalN/lipopolysaccharide (LPS) in addition to liver injury induced GalN. Nobiletin suppressed GalN/LPS-induced increases in plasma tumor necrosis factor (TNF)-alpha and nitric oxide (NO) concentrations and hepatic mRNA levels for inducible NO synthase and DNA fragmentation. These results suggest that nobiletin suppressed GalN/LPS-induced liver injury at least by suppressing the production of both TNF-alpha and NO. The results obtained here indicate that the hepatoprotective effect of shekwasha juice is mainly ascribed to several polymethoxy flavonoids included in the juice.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetaminophen,
http://linkedlifedata.com/resource/pubmed/chemical/Alanine Transaminase,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartate Aminotransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Flavones,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Galactosamine,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/nobiletin
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1881-7742
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
56
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
60-7
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| pubmed:meshHeading |
pubmed-meshheading:20354348-Acetaminophen,
pubmed-meshheading:20354348-Alanine Transaminase,
pubmed-meshheading:20354348-Animals,
pubmed-meshheading:20354348-Aspartate Aminotransferases,
pubmed-meshheading:20354348-Carbon Tetrachloride Poisoning,
pubmed-meshheading:20354348-Citrus,
pubmed-meshheading:20354348-DNA Fragmentation,
pubmed-meshheading:20354348-Drug-Induced Liver Injury,
pubmed-meshheading:20354348-Flavones,
pubmed-meshheading:20354348-Flavonoids,
pubmed-meshheading:20354348-Galactosamine,
pubmed-meshheading:20354348-Lipopolysaccharides,
pubmed-meshheading:20354348-Liver,
pubmed-meshheading:20354348-Male,
pubmed-meshheading:20354348-Molecular Structure,
pubmed-meshheading:20354348-Nitric Oxide,
pubmed-meshheading:20354348-Nitric Oxide Synthase Type II,
pubmed-meshheading:20354348-Phytotherapy,
pubmed-meshheading:20354348-Plant Extracts,
pubmed-meshheading:20354348-RNA, Messenger,
pubmed-meshheading:20354348-Rats,
pubmed-meshheading:20354348-Rats, Wistar,
pubmed-meshheading:20354348-Tumor Necrosis Factor-alpha
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| pubmed:year |
2010
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| pubmed:articleTitle |
Hepatoprotective effects of flavonoids from shekwasha (Citrus depressa) against D-galactosamine-induced liver injury in rats.
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| pubmed:affiliation |
The United Graduate School of Agricultural Science, Gifu University, Gifu, Japan. acksugi@agr.shizuoka.ac.jp
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| pubmed:publicationType |
Journal Article
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