Source:http://linkedlifedata.com/resource/pubmed/id/20351032
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2010-10-4
|
| pubmed:abstractText |
Lung involvement is the leading cause of death in systemic sclerosis (SSc), but lung transplantation (LT) for systemic disease remains controversial. Our objective was to comprehensively evaluate post-LT outcomes for SSc compared to idiopathic pulmonary fibrosis (IPF). We retrospectively evaluated bilateral LT recipients (LTRs) with SSc or IPF at our centre between January 1, 2003 and December 31, 2007. The primary end-point was all-cause mortality at 1 yr post-LT. Secondary end-points included assessments of acute rejection (AR), pulmonary function, infection and chronic rejection. 14 patients with SSc and 38 patients with IPF underwent LT. Apart from a younger SSc cohort (53.2 versus 58.8 yrs; p = 0.02), the two groups were well matched. 1-yr all-cause mortality was no different between SSc (6.6%) and IPF (13.1%) groups, after adjusting for age (p = 0.62). Rates of (AR) ?2 were significantly increased for the SSc compared with the IPF group (hazard ratio (HR) 2.91; p = 0.007). Other end-points, including chronic rejection, infection and pulmonary function, showed no differences. SSc LTRs experience similar survival 1 yr post-LT when compared to IPF. AR rates may be significantly higher in the SSc group. Longer follow-up is necessary to determine the effects of gastrointestinal dysfunction and AR on late allograft function in SSc LTR.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1399-3003
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| pubmed:author |
pubmed-author:ArdehaliAA,
pubmed-author:BelperioJ AJA,
pubmed-author:ClementsP JPJ,
pubmed-author:DerhovanessianAA,
pubmed-author:FishbeinM CMC,
pubmed-author:FurstD EDE,
pubmed-author:GregsonAA,
pubmed-author:HunterCC,
pubmed-author:KhannaDD,
pubmed-author:KubatKK,
pubmed-author:Lynch IiiJ PJP,
pubmed-author:ParkG SGS,
pubmed-author:RiseN LNL,
pubmed-author:SaggarRR,
pubmed-author:ShapiroSS,
pubmed-author:WeigtS SSS
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
893-900
|
| pubmed:dateRevised |
2011-10-3
|
| pubmed:meshHeading |
pubmed-meshheading:20351032-Adult,
pubmed-meshheading:20351032-Algorithms,
pubmed-meshheading:20351032-Cohort Studies,
pubmed-meshheading:20351032-Female,
pubmed-meshheading:20351032-Humans,
pubmed-meshheading:20351032-Immunosuppressive Agents,
pubmed-meshheading:20351032-Lung Transplantation,
pubmed-meshheading:20351032-Male,
pubmed-meshheading:20351032-Middle Aged,
pubmed-meshheading:20351032-Patient Compliance,
pubmed-meshheading:20351032-Pulmonary Fibrosis,
pubmed-meshheading:20351032-Retrospective Studies,
pubmed-meshheading:20351032-Scleroderma, Systemic,
pubmed-meshheading:20351032-Time Factors,
pubmed-meshheading:20351032-Treatment Outcome
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Systemic sclerosis and bilateral lung transplantation: a single centre experience.
|
| pubmed:affiliation |
Division of Pulmonary and Critical Care Medicine, Dept of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1690, USA. rsaggar@mednet.ucla.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|