|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2010-6-2
|
|
pubmed:abstractText |
Interleukin (IL)-6 secretion from macrophage cells is known to be induced by toll-like receptor (TLR) 9 ligands, CpG (microbial DNA sequences containing unmethylated CpG dinucleotides). We have found, using macrophage-like J774.1 cells, that this induction was dramatically suppressed by a disaccharide derived from chondroitin sulfate A (Di-4S), but not by chondroitin sulfate A (CS-A) itself. The suppression of IL-6 secretion by Di-4S occurred at protein and mRNA expression levels. Di-4S inhibited the degradation of interleukin-1 receptor-associated kinase 1 (IRAK1) in the signaling pathway mediated by myeloid differentiation primary response gene (88) (MyD88) when stimulated by TLR9 activation. In addition to suppressing IRAK1 activation, interference with CpG-TLR9 interaction by Di-4S is also suggested to be one of the mechanisms. Oligosaccharides derived from chondroitin sulfates would be effective suppressing agents for the TLR9-mediated inflammation reaction.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Chondroitin Sulfates,
http://linkedlifedata.com/resource/pubmed/chemical/Dinucleoside Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Disaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1 Receptor-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Irak1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Pam(3)CSK(4) peptide,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 9,
http://linkedlifedata.com/resource/pubmed/chemical/cytidylyl-3'-5'-guanosine
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1096-0023
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
51
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
53-9
|
|
pubmed:meshHeading |
pubmed-meshheading:20350813-Animals,
pubmed-meshheading:20350813-Cell Extracts,
pubmed-meshheading:20350813-Cell Line,
pubmed-meshheading:20350813-Chondroitin Sulfates,
pubmed-meshheading:20350813-Chromatography, Gel,
pubmed-meshheading:20350813-Dinucleoside Phosphates,
pubmed-meshheading:20350813-Disaccharides,
pubmed-meshheading:20350813-Gene Expression Regulation,
pubmed-meshheading:20350813-Interleukin-1 Receptor-Associated Kinases,
pubmed-meshheading:20350813-Interleukin-6,
pubmed-meshheading:20350813-Lipopeptides,
pubmed-meshheading:20350813-Lipopolysaccharides,
pubmed-meshheading:20350813-Macrophages,
pubmed-meshheading:20350813-Mice,
pubmed-meshheading:20350813-Models, Biological,
pubmed-meshheading:20350813-Phagocytosis,
pubmed-meshheading:20350813-Protein Binding,
pubmed-meshheading:20350813-Protein Processing, Post-Translational,
pubmed-meshheading:20350813-RNA, Messenger,
pubmed-meshheading:20350813-Toll-Like Receptor 9
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Disaccharide derived from chondroitin sulfate A suppressed CpG-induced IL-6 secretion in macrophage-like J774.1 cells.
|
|
pubmed:affiliation |
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. jinmiaollh@hotmail.com
|
|
pubmed:publicationType |
Journal Article
|
