Linked Life Data

20350805

Source:http://linkedlifedata.com/resource/pubmed/id/20350805

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-4-20
pubmed:abstractText
A bivalent tethered approach toward YopH inhibitor development is presented that joins aldehydes with mixtures of bis-aminooxy-containing linkers using oxime coupling. The methodology is characterized by its facility and ease of use and its ability to rapidly identify low micromolar affinity inhibitors. The generality of the approach may potentially make it amenable to the development of bivalent inhibitors directed against other phosphatases.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-10716979, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-12190316, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-14521410, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-14609321, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-15139811, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-15158797, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-15482920, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-15615724, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-15743199, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-15781408, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-16332091, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-16468749, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-16557282, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-16570910, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-17017875, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-17046267, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-17998804, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-18056643, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-18298793, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-18457385, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-18457404, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-19199933, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-19396178, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-19852491, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-7515682, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350805-7524496
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1464-3405
pubmed:author
pubmed:copyrightInfo
Published by Elsevier Ltd.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2813-6
pubmed:dateRevised
2011-9-29
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH.
pubmed:affiliation
Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, NCI-Frederick, Frederick, MD 21702, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Intramural