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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23-24
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pubmed:dateCreated |
2010-5-24
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pubmed:abstractText |
Estrogen acts as a neurogenerative and neuroprotective factor in the cholinergic system. Choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) are regarded as markers of cholinergic neurons. The genes coding these proteins are located at a common locus, the cholinergic gene locus. However, few details concerning activation of the locus have been obtained. We examined the effect of estrogen on the activation pattern of the locus using a cholinergic cell line.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1879-0631
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
839-43
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pubmed:meshHeading |
pubmed-meshheading:20350555-Animals,
pubmed-meshheading:20350555-Choline O-Acetyltransferase,
pubmed-meshheading:20350555-Cholinergic Fibers,
pubmed-meshheading:20350555-Dose-Response Relationship, Drug,
pubmed-meshheading:20350555-Estradiol,
pubmed-meshheading:20350555-Estrogen Antagonists,
pubmed-meshheading:20350555-Gene Expression,
pubmed-meshheading:20350555-Genes,
pubmed-meshheading:20350555-Hybrid Cells,
pubmed-meshheading:20350555-Mice,
pubmed-meshheading:20350555-Organic Chemicals,
pubmed-meshheading:20350555-RNA, Messenger,
pubmed-meshheading:20350555-Rats,
pubmed-meshheading:20350555-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20350555-Tretinoin,
pubmed-meshheading:20350555-Up-Regulation,
pubmed-meshheading:20350555-Vesicular Acetylcholine Transport Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
Asymmetric regulation by estrogen at the cholinergic gene locus in differentiated NG108-15 neuronal cells.
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pubmed:affiliation |
Department of Animal Science, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa 252-8510, Japan. yamamuro@brs.nihon-u.ac.jp <yamamuro@brs.nihon-u.ac.jp>
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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