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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2010-6-22
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pubmed:abstractText |
Serotonin plays a key role in modulating various physiological and behavioral processes in both protostomes and deuterostomes. The vast majority of serotonin receptors belong to the superfamily of G-protein-coupled receptors. We report the cloning of a cDNA from the honeybee (Am5-ht1A) sharing high similarity with members of the 5-HT(1) receptor class. Activation of Am5-HT(1A) by serotonin inhibited the production of cAMP in a dose-dependent manner (EC(50) = 16.9 nM). Am5-HT(1A) was highly expressed in brain regions known to be involved in visual information processing. Using in vivo pharmacology, we could demonstrate that Am5-HT(1A) receptor ligands had a strong impact on the phototactic behavior of individual bees. The data presented here mark the first comprehensive study-from gene to behavior-of a 5-HT(1A) receptor in the honeybee, paving the way for the eventual elucidation of additional roles of this receptor subtype in the physiology and behavior of this social insect.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1420-9071
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2467-79
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20349263-Amino Acid Sequence,
pubmed-meshheading:20349263-Animals,
pubmed-meshheading:20349263-Bees,
pubmed-meshheading:20349263-Behavior, Animal,
pubmed-meshheading:20349263-Brain,
pubmed-meshheading:20349263-Humans,
pubmed-meshheading:20349263-Immunohistochemistry,
pubmed-meshheading:20349263-Insect Proteins,
pubmed-meshheading:20349263-Ligands,
pubmed-meshheading:20349263-Light,
pubmed-meshheading:20349263-Molecular Sequence Data,
pubmed-meshheading:20349263-Movement,
pubmed-meshheading:20349263-Mushroom Bodies,
pubmed-meshheading:20349263-Optic Lobe, Nonmammalian,
pubmed-meshheading:20349263-Prazosin,
pubmed-meshheading:20349263-Receptor, Serotonin, 5-HT1A,
pubmed-meshheading:20349263-Serotonin,
pubmed-meshheading:20349263-Serotonin Antagonists,
pubmed-meshheading:20349263-Serotonin Receptor Agonists
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pubmed:year |
2010
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pubmed:articleTitle |
Characterization of the 5-HT1A receptor of the honeybee (Apis mellifera) and involvement of serotonin in phototactic behavior.
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pubmed:affiliation |
Institute of Biochemistry and Biology, Animal Physiology, University of Potsdam, Potsdam, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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