|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2010-4-20
|
|
pubmed:abstractText |
In previous studies, we identified a truxillic acid derivative as selective activator of the peroxisome proliferator-activated receptor gamma, which is a member of the nuclear receptor family and acts as ligand-activated transcription factor of genes involved in glucose metabolism. Herein we present the structure-activity relationships of 16 truxillic acid derivatives, investigated by a cell-based reporter gene assay guided by molecular docking analysis.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1464-3405
|
|
pubmed:author |
pubmed-author:HansenKatjaK,
pubmed-author:Müller-KuhrtLutzL,
pubmed-author:MüllerKlaus-RobertKR,
pubmed-author:ProschakEwgenijE,
pubmed-author:RuppMatthiasM,
pubmed-author:SchneiderGisbertG,
pubmed-author:SchroeterTimonT,
pubmed-author:Schubert-ZsilaveczManfredM,
pubmed-author:SchwarzOliverO,
pubmed-author:SteriRamonaR,
pubmed-author:ZettlHeikoH
|
|
pubmed:copyrightInfo |
2010 Elsevier Ltd. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2920-3
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators.
|
|
pubmed:affiliation |
Goethe-University Frankfurt, Institute of Pharmaceutical Chemistry/ZAFES/LiFF/FIRST, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany. steri@pharmchem.uni-frankfurt.de
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
