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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-5-3
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pubmed:abstractText |
Bcl-xL, an anti-apoptotic member of the Bcl-2 family, is over-expressed in human hepatocellular carcinoma, conferring a survival advantage to tumour cells. The mechanisms underlying its dysregulation have not been clarified. In the present study, we explored the involvement of microRNAs that act as endogenous sequence-specific suppressors of gene expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzenesulfonates,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin G1,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/MicroRNAs,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Staurosporine,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-X Protein,
http://linkedlifedata.com/resource/pubmed/chemical/sorafenib
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0168-8278
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pubmed:author |
pubmed-author:DokiYuichiroY,
pubmed-author:HayashiNorioN,
pubmed-author:HikitaHayatoH,
pubmed-author:HosuiAtsushiA,
pubmed-author:IshidaHisashiH,
pubmed-author:KodamaTakahiroT,
pubmed-author:MiyagiTakuyaT,
pubmed-author:MoriMasakiM,
pubmed-author:NaganoHiroakiH,
pubmed-author:NodaTakehiroT,
pubmed-author:ShimizuSatoshiS,
pubmed-author:TakeharaTetsuoT,
pubmed-author:TatsumiTomohideT
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pubmed:copyrightInfo |
Copyright (c) 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
698-704
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pubmed:meshHeading |
pubmed-meshheading:20347499-Antineoplastic Agents,
pubmed-meshheading:20347499-Apoptosis,
pubmed-meshheading:20347499-Base Sequence,
pubmed-meshheading:20347499-Benzenesulfonates,
pubmed-meshheading:20347499-Carcinoma, Hepatocellular,
pubmed-meshheading:20347499-Cyclin G1,
pubmed-meshheading:20347499-Down-Regulation,
pubmed-meshheading:20347499-Drug Synergism,
pubmed-meshheading:20347499-Enzyme Inhibitors,
pubmed-meshheading:20347499-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20347499-Humans,
pubmed-meshheading:20347499-Liver Neoplasms,
pubmed-meshheading:20347499-MicroRNAs,
pubmed-meshheading:20347499-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:20347499-Pyridines,
pubmed-meshheading:20347499-RNA, Messenger,
pubmed-meshheading:20347499-RNA, Neoplasm,
pubmed-meshheading:20347499-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20347499-Staurosporine,
pubmed-meshheading:20347499-Up-Regulation,
pubmed-meshheading:20347499-bcl-X Protein
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pubmed:year |
2010
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pubmed:articleTitle |
The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma.
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pubmed:affiliation |
Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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