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rdf:type |
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lifeskim:mentions |
umls-concept:C0014406,
umls-concept:C0025810,
umls-concept:C0031809,
umls-concept:C0034693,
umls-concept:C0205309,
umls-concept:C0205314,
umls-concept:C0234402,
umls-concept:C0558295,
umls-concept:C0599946,
umls-concept:C0679622,
umls-concept:C1428114
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pubmed:issue |
1
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pubmed:dateCreated |
2010-5-5
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pubmed:abstractText |
Methylphenidate is a psychostimulant widely used in the treatment of attention deficit hyperactivity disorder (ADHD). Here we report a novel paradigm that affords inferences about habituation and attention to a novel stimulus in a familiar environment in a single test session without prior training of the animals. The paradigm was used to assess the effects of methylphenidate (2.5 and 5.0mg/kg, sc) in young adult, male, Long-Evans rats. Methylphenidate increased locomotor activity during the initial exposure to the test apparatus in a non-dose-related manner. However, upon introduction of a novel spatial stimulus (an alcove) in the familiar environment, methylphenidate-treatment resulted in dose-related increases in distance traveled and inhibition of long dwell times in the alcove, the latter behavior being characteristic of vehicle-treated rats' response to the alcove condition. These results demonstrate the utility of this paradigm in the elucidation of the behavioral effects of a drug commonly used in the treatment of ADHD. Findings also suggest that species-typical response preferences in rats (e.g., refuge-seeking) may emerge in experimental settings that add spatial novelty to otherwise featureless test enclosures commonly used to assess locomotor activity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-10580312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-11181919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-1170715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-11716816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-12177221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-16624396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-16678279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-16764915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-16774787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-1745717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-1813925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-18614672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-19229521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-19641108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-2233902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-2783366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-2794253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-4397666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-4622973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-5080151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-5260289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-5712878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-7243422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-7550615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-7952288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-7990511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-9065532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-9502834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20346982-9708834
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1872-678X
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2010 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
189
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
36-43
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20346982-Animals,
pubmed-meshheading:20346982-Attention,
pubmed-meshheading:20346982-Behavior, Animal,
pubmed-meshheading:20346982-Behavioral Research,
pubmed-meshheading:20346982-Brain,
pubmed-meshheading:20346982-Central Nervous System Stimulants,
pubmed-meshheading:20346982-Dose-Response Relationship, Drug,
pubmed-meshheading:20346982-Electronics, Medical,
pubmed-meshheading:20346982-Environment, Controlled,
pubmed-meshheading:20346982-Equipment Design,
pubmed-meshheading:20346982-Exploratory Behavior,
pubmed-meshheading:20346982-Male,
pubmed-meshheading:20346982-Methylphenidate,
pubmed-meshheading:20346982-Motor Activity,
pubmed-meshheading:20346982-Psychopharmacology,
pubmed-meshheading:20346982-Rats,
pubmed-meshheading:20346982-Rats, Long-Evans,
pubmed-meshheading:20346982-Space Perception
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pubmed:year |
2010
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pubmed:articleTitle |
Methylphenidate attenuates rats' preference for a novel spatial stimulus introduced into a familiar environment: assessment using a force-plate actometer.
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pubmed:affiliation |
Department of Pharmacology & Toxicology, University of Kansas, Lawrence, KS 66045, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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