Source:http://linkedlifedata.com/resource/pubmed/id/20346059
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2010-7-28
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| pubmed:abstractText |
Puerarin (4'-7-dihydroxy-8-beta-D-glucosylisoflavone), the most abundant isoflavone-C-glucoside extracted from the root of the plant Pueraria lobata, has demonstrated anti-inflammatory activity in cellular models of inflammation. In this report, we examined the ability of puerarin to modulate C-reactive protein (CRP) expression and key molecules in the nuclear factor kappa B (NF-kappaB) pathway to determine its molecular target. The protein and mRNA levels of CRP were determined in lipopolysaccharide (LPS)-induced peripheral blood mononuclear cells of patients with unstable angina pectoris. Also, we detected the I-kappaBalpha phosphorylation and the p65NF-kappaB expression in peripheral blood mononuclear cells under our experimental condition. The results indicated that puerarin inhibited the expression of the protein and mRNA levels of CRP in LPS-induced peripheral blood mononuclear cells. Subsequently, we determined that the inhibition of CRP expression was because of a dose-dependent inhibition of phosphorylation and degradation of inhibitor kappaB(I-kappaB), which resulted in a reduction of p65NF-kappaB nuclear translocation. We conclude that puerarin acts as an anti-inflammatory agent by blocking NF-kappaB signalling, and may possibly be developed as a useful agent for the chemoprevention of atherosclerosis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/C-Reactive Protein,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflavones,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor RelA,
http://linkedlifedata.com/resource/pubmed/chemical/puerarin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1742-7843
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
107
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
637-42
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| pubmed:meshHeading |
pubmed-meshheading:20346059-Aged,
pubmed-meshheading:20346059-Angina Pectoris,
pubmed-meshheading:20346059-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:20346059-C-Reactive Protein,
pubmed-meshheading:20346059-Cell Survival,
pubmed-meshheading:20346059-Cells, Cultured,
pubmed-meshheading:20346059-Female,
pubmed-meshheading:20346059-Gene Expression,
pubmed-meshheading:20346059-Humans,
pubmed-meshheading:20346059-I-kappa B Proteins,
pubmed-meshheading:20346059-Isoflavones,
pubmed-meshheading:20346059-Leukocytes, Mononuclear,
pubmed-meshheading:20346059-Lipopolysaccharides,
pubmed-meshheading:20346059-Male,
pubmed-meshheading:20346059-Middle Aged,
pubmed-meshheading:20346059-NF-kappa B,
pubmed-meshheading:20346059-Phosphorylation,
pubmed-meshheading:20346059-Plant Extracts,
pubmed-meshheading:20346059-Pueraria,
pubmed-meshheading:20346059-Transcription Factor RelA,
pubmed-meshheading:20346059-Transcriptional Activation
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| pubmed:year |
2010
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| pubmed:articleTitle |
Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris.
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| pubmed:affiliation |
Department of Cardiology, First Affiliated Hospital of Soochow University, Soochow, China.
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| pubmed:publicationType |
Journal Article
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