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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-7-29
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pubmed:abstractText |
Basal cell carcinoma (BCC) is 10 times more frequent in organ transplant recipients (OTRs) than in the general population. Factors in OTRs conferring increased susceptibility to BCC include ultraviolet radiation exposure, immunosuppression, viral infections such as human papillomavirus, phototype and genetic predisposition. The PTCH1 gene is a negative regulator of the hedgehog pathway, that provides mitogenic signals to basal cells in skin. PTCH1 gene mutations cause naevoid BCC syndrome, and contribute to the development of sporadic BCC and other types of cancers. Associations have been reported between PTCH1 polymorphisms and BCC susceptibility in nontransplanted individuals.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1365-2133
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pubmed:author |
pubmed-author:BegniniAA,
pubmed-author:BoschieroLL,
pubmed-author:BrunelloAA,
pubmed-author:CasconeCC,
pubmed-author:ForniAA,
pubmed-author:FortinaA BAB,
pubmed-author:GirolomoniGG,
pubmed-author:Gomez LiraMM,
pubmed-author:GottiEE,
pubmed-author:MalerbaGG,
pubmed-author:NaldiLL,
pubmed-author:PiasericoSS,
pubmed-author:RugiuCC,
pubmed-author:TessariGG,
pubmed-author:TurcoAA
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pubmed:issnType |
Electronic
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pubmed:volume |
163
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
364-70
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pubmed:meshHeading |
pubmed-meshheading:20346027-Adolescent,
pubmed-meshheading:20346027-Adult,
pubmed-meshheading:20346027-Aged,
pubmed-meshheading:20346027-Carcinoma, Basal Cell,
pubmed-meshheading:20346027-Exons,
pubmed-meshheading:20346027-Female,
pubmed-meshheading:20346027-Gene Frequency,
pubmed-meshheading:20346027-Genotype,
pubmed-meshheading:20346027-Haplotypes,
pubmed-meshheading:20346027-Humans,
pubmed-meshheading:20346027-Male,
pubmed-meshheading:20346027-Middle Aged,
pubmed-meshheading:20346027-Organ Transplantation,
pubmed-meshheading:20346027-Polymorphism, Genetic,
pubmed-meshheading:20346027-Receptors, Cell Surface,
pubmed-meshheading:20346027-Skin Neoplasms,
pubmed-meshheading:20346027-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
PTCH1 gene haplotype association with basal cell carcinoma after transplantation.
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pubmed:affiliation |
Department of Mother and Child, Section of Biology and Genetics, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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