20339121

Source:http://linkedlifedata.com/resource/pubmed/id/20339121

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0005495, umls-concept:C0018787, umls-concept:C0086418, umls-concept:C0220781, umls-concept:C0521451, umls-concept:C0598312
pubmed:issue	9
pubmed:dateCreated	2010-5-14
pubmed:abstractText	Mitochondrial dysfunction plays a pivotal role in the development of heart failure. Animal studies suggest that impaired mitochondrial biogenesis attributable to downregulation of the peroxisome proliferator-activated receptor gamma coactivator (PGC)-1 transcriptional pathway is integral of mitochondrial dysfunction in heart failure.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R01 HL059246-10A1, http://linkedlifedata.com/resource/pubmed/grant/R01 HL067970-08, http://linkedlifedata.com/resource/pubmed/grant/R01 HL088634-04
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0047103
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/DNA, Mitochondrial, http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins, http://linkedlifedata.com/resource/pubmed/chemical/PPARGC1A protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	1524-4571
pubmed:author	pubmed-author:CouperGregory SGS, pubmed-author:KaramanlidisGeorgiosG, pubmed-author:NascimbenLuiginoL, pubmed-author:NazSS, pubmed-author:ShekarPrem SPS, pubmed-author:del MonteFedericaF
pubmed:issnType	Electronic
pubmed:day	14
pubmed:volume	106
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1541-8
pubmed:dateRevised	2011-9-26
pubmed:meshHeading	pubmed-meshheading:20339121-Adult, pubmed-meshheading:20339121-Aged, pubmed-meshheading:20339121-DNA, Mitochondrial, pubmed-meshheading:20339121-DNA Replication, pubmed-meshheading:20339121-Down-Regulation, pubmed-meshheading:20339121-Female, pubmed-meshheading:20339121-Heart Failure, pubmed-meshheading:20339121-Heat-Shock Proteins, pubmed-meshheading:20339121-Humans, pubmed-meshheading:20339121-Male, pubmed-meshheading:20339121-Middle Aged, pubmed-meshheading:20339121-Mitochondria, pubmed-meshheading:20339121-Transcription Factors, pubmed-meshheading:20339121-Young Adult
pubmed:year	2010
pubmed:articleTitle	Defective DNA replication impairs mitochondrial biogenesis in human failing hearts.
pubmed:affiliation	Department of Medicine, University of Washington, Seattle, WA, USA.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural