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rdf:type |
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lifeskim:mentions |
umls-concept:C0001898,
umls-concept:C0002520,
umls-concept:C0007137,
umls-concept:C0017337,
umls-concept:C0017890,
umls-concept:C0035647,
umls-concept:C0332281,
umls-concept:C0460004,
umls-concept:C0752046,
umls-concept:C1412242,
umls-concept:C1555721,
umls-concept:C1706204
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pubmed:issue |
12
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pubmed:dateCreated |
2010-6-21
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pubmed:abstractText |
The authors conducted a hospital-based study of 1110 patients with squamous cell carcinoma of the head and neck (SCCHN) and a control group of 1129 patients to replicate the associations reported by a recent, large European study between 2 potentially functional single nucleotide polymorphisms (SNPs) of the alcohol dehydrogenase (ADH) genes, a substitution in ADH1B at amino acid 48 from arginine to histidine (R48H) (reference SNP number [rs]1229984; guanine to adenine [G-->A]) and a substitution in ADH7 at amino acid 92 from alanine to glycine (A92G) (rs1573496; cytosine to guanine [C-->G]), and the risk of squamous cell carcinoma of the head and neck (SCCHN).
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-10090900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-10441588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-12050823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-12419833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-12668919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-14693654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-15026468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-15048643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-15599850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-15734975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-15761078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-15767341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-15861040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-1592118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-16287084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-16385178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-16571603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-16614111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-17071628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-17489985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-17505073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-17575128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-17646865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-17718394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-17718399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-17847010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-17921519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-18033686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-18382665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-18500343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-19185835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-8488982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-8503936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20336794-8974326
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2984-92
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:20336794-Alcohol Dehydrogenase,
pubmed-meshheading:20336794-Carcinoma, Squamous Cell,
pubmed-meshheading:20336794-Female,
pubmed-meshheading:20336794-Genetic Predisposition to Disease,
pubmed-meshheading:20336794-Head and Neck Neoplasms,
pubmed-meshheading:20336794-Humans,
pubmed-meshheading:20336794-Male,
pubmed-meshheading:20336794-Middle Aged,
pubmed-meshheading:20336794-Polymorphism, Single Nucleotide,
pubmed-meshheading:20336794-Risk,
pubmed-meshheading:20336794-Smoking
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pubmed:year |
2010
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pubmed:articleTitle |
A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck.
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pubmed:affiliation |
Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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