Linked Life Data

20336591

Source:http://linkedlifedata.com/resource/pubmed/id/20336591

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-3-25
pubmed:abstractText
The kisspeptin/kisspeptin receptor (KISS1R) system is a critical regulator of reproductive function. The kisspeptins are potent stimulators of the hypothalamic-pituitary-gonadal (HPG) axis via their actions ongonadotropin-releasing hormone. Therefore, kisspeptins represent putative drug targets for the treatment of reproductive diseases. Kisspeptins of 10, 13, 14 and 54 amino acids in length have been identified, all of which contain a C-terminal decapeptide that is essential for biological activity. The longest form, kisspeptin-54, may be the most bioactive in vivo. Moreover, the pattern of kisspeptin administration is important; whereas single or intermittent injections of kisspeptin generally stimulate the HPG axis, continuous administration leads to the desensitization of the HPG axis to the effects of the peptide. Several kisspeptin analogs have been developed, and are discussed in relation to their activity at the KISS1R and to their in vivo HPG axis effects.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
2040-3429
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
432-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Modulation of the hypothalamic-pituitary-gonadal axis by selective ligands of the KISS1R.
pubmed:affiliation
Imperial College London, Faculty of Medicine, Department of Investigative Medicine, Commonwealth Building, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't