Linked Life Data

20335374

Source:http://linkedlifedata.com/resource/pubmed/id/20335374

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-5-25
pubmed:abstractText
Murine reperfusion injury follows binding of specific IgM natural antibodies to neo-antigens exposed in ischemic tissue. Peptides that mimic the site of antibody binding in the injury prevent IgM binding when administered intravenously before reperfusion. To determine whether this pathogenic sequence is restricted to mice, we have tested the ability of the peptide to prevent reperfusion injury in a dissimilar species, the rat. Sprague-Dawley rats were subjected to 40 min of mesenteric ischemia followed by 180 min of reperfusion. The peptide mimic was administered intravenously prior to reperfusion. Gut injury was quantified using a scoring system based on the hematoxylin-and-eosin section. (125)I-labeled albumin was used to assess local (gut) and remote (lung) injury. The macroscopic appearance of bowel from peptide-treated animals was less edematous and hemorrhagic. Microscopic analysis showed a significantly reduced injury score in peptide-treated animals. Permeability data indicated a significant reduction in local and remote injury in peptide-treated animals. The data demonstrate attenuation of rat gut microvillus injury, of gut edema, and of remote injury following mesenteric ischemia-reperfusion due to administration of an intravenous peptide mimic of a murine ischemia neo-antigen, indicating a second species uses a similar ischemia neo-antigen and corresponding natural antibody specificity to amplify reperfusion injury to the point of necrosis. This mechanism of inflammation is potentially applicable to higher species.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-10066708, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-11319262, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-12165541, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-12421918, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-12552136, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-1387151, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-14999103, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-15057822, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-15300207, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-15879138, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-15905575, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-16390934, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-16455333, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-16982912, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-17360462, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-2371562, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-4993831, http://linkedlifedata.com/resource/pubmed/commentcorrection/20335374-8642343
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1522-1490
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
298
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R1675-81
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Inhibition of rat gut reperfusion injury with an agent developed for the mouse. Evidence that amplification of injury by innate immunity is conserved between two animal species.
pubmed:affiliation
Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural