Linked Life Data

20334607

Source:http://linkedlifedata.com/resource/pubmed/id/20334607

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-3-25
pubmed:abstractText
In acute lung injuries, secretory phospholipase A(2) (sPLA(2)) inhibits surfactants by hydrolyzing phospholipids. Because hyaluronan (HA) reduces hydrolysis of phospholipids by sPLA(2), and because sPLA(2) inhibits surfactant in vitro, the authors hypothesized HA would reduce sPLA(2) inhibition. Surfactants were used alone or mixed with HA and/or sPLA(2) then tested for surface activity in 2 separate assays, or for sPLA(2) activity. Equilibrium surface pressures were identical for surfactant with or without HA. sPLA(2) inhibited surface activity but this inhibitory effect was reduced with HA by 14% in the spreading trough and by 63% in a modified bubble surfactometer. Hyaluronan caused a modest reduction (39%) of sPLA(2) breakdown of labeled phospholipid. Therefore hyaluronan reduces inhibition of surfactants by sPLA(2) in vitro, and reduces the activity of the enzyme.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1521-0499
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-74
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Reductions of phospholipase A(2) inhibition of pulmonary surfactant with hyaluronan.
pubmed:affiliation
Department of Pediatrics, University of California-San Francisco, San Francisco, California, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural