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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4-5
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pubmed:dateCreated |
2010-3-24
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pubmed:abstractText |
Screening of drug safety is typically performed in diverse non-human healthy species with an intact repolarization reserve. Nevertheless, these drugs are later applied in diseased humans with a reduced repolarization reserve. It would be optimal to set up a preclinical screening tool to estimate the proarrhythmic potential of drugs in human cardiac tissue with a reduced repolarization reserve in vitro.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1421-9778
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pubmed:author |
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pubmed:copyrightInfo |
2010 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
459-66
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pubmed:meshHeading |
pubmed-meshheading:20332627-Action Potentials,
pubmed-meshheading:20332627-Animals,
pubmed-meshheading:20332627-Anti-Arrhythmia Agents,
pubmed-meshheading:20332627-Dose-Response Relationship, Drug,
pubmed-meshheading:20332627-Drug Evaluation, Preclinical,
pubmed-meshheading:20332627-Embryonic Stem Cells,
pubmed-meshheading:20332627-Humans,
pubmed-meshheading:20332627-Mice,
pubmed-meshheading:20332627-Myocytes, Cardiac,
pubmed-meshheading:20332627-Quinidine,
pubmed-meshheading:20332627-Sotalol,
pubmed-meshheading:20332627-Verapamil
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pubmed:year |
2010
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pubmed:articleTitle |
Human and murine embryonic stem cell-derived cardiomyocytes serve together as a valuable model for drug safety screening.
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pubmed:affiliation |
Institute of Neurophysiology, University of Cologne, Cologne, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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