Linked Life Data

20332437

Source:http://linkedlifedata.com/resource/pubmed/id/20332437

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-3-24
pubmed:abstractText
The most common neoplasm arising in the upper gastrointestinal tract is head and neck squamous cell carcinoma (HNSCC). This is an aggressive epithelial malignancy. Many growth factors and cytokines have been discovered that are responsible for the growth and formation of tumours. Among these factors, beta-catenin is considered to be the most important for reducing cell-cell adhesions in malignant tissue. The degradation of beta-catenin triggers apoptosis by different routes. Sulindac sulfone has been shown to induce apoptosis in several different tumours. In the present study, we surveyed the concentration of beta-catenin in an HNSCC line after incubation with different concentrations of sulindac sulfone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1791-7530
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
339-43
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Sulindac sulfone induces a decrease of beta-catenin in HNSCC.
pubmed:affiliation
Department of Otolaryngology, Head and Neck Surgery, Universitaets-HNO-Klinik, Theodor-Kutzer-Ufer, D-68135 Mannheim, Germany. alexander.sauter@gmail.com
pubmed:publicationType
Journal Article