Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-5-17
pubmed:abstractText
Rat models of orofacial cancer exhibit both allodynia and hyperalgesia; however, it is unclear whether cancer-induced pain is secondary to cancer-induced inflammation. To address this question, we compared the effects of an anti-inflammatory drug, indomethacin, on pain and neurochemical changes in the medullary dorsal horn in orofacial inflammation and cancer models. Daily peripheral administration of indomethacin largely suppressed mechanical allodynia and thermal hyperalgesia in the inflammation model. The same procedure suppressed allodynia and hyperalgesia in the cancer model, but the suppression was weak when compared with that in the inflammation model. In the medullary dorsal horn, calcitonin gene-related peptide and substance P levels were significantly increased in the inflammation model, but did not change in the cancer model. These results suggest that pain in the orofacial cancer model is not significantly mediated by cancer-induced peripheral inflammation, although it may have some involvement.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1544-0591
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
615-20
pubmed:meshHeading
pubmed-meshheading:20332329-Animals, pubmed-meshheading:20332329-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:20332329-Calcitonin Gene-Related Peptide, pubmed-meshheading:20332329-Carcinoma 256, Walker, pubmed-meshheading:20332329-Disease Models, Animal, pubmed-meshheading:20332329-Facial Neoplasms, pubmed-meshheading:20332329-Facial Pain, pubmed-meshheading:20332329-Galanin, pubmed-meshheading:20332329-Hot Temperature, pubmed-meshheading:20332329-Hyperalgesia, pubmed-meshheading:20332329-Indomethacin, pubmed-meshheading:20332329-Inflammation, pubmed-meshheading:20332329-Injections, Intraperitoneal, pubmed-meshheading:20332329-Male, pubmed-meshheading:20332329-Neuropeptides, pubmed-meshheading:20332329-Neurotransmitter Agents, pubmed-meshheading:20332329-Pain Threshold, pubmed-meshheading:20332329-Physical Stimulation, pubmed-meshheading:20332329-Rats, pubmed-meshheading:20332329-Rats, Wistar, pubmed-meshheading:20332329-Reaction Time, pubmed-meshheading:20332329-Substance P, pubmed-meshheading:20332329-Touch, pubmed-meshheading:20332329-Trigeminal Caudal Nucleus, pubmed-meshheading:20332329-Vibrissae
pubmed:year
2010
pubmed:articleTitle
Differences between orofacial inflammation and cancer pain.
pubmed:affiliation
Department of Control of Physical Functions, Kyushu Dental College, 2-6-1 Manazuru, Kokurakitaku, Kitakyushu, Fukuoka, 803-8580, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't