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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-5-13
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pubmed:abstractText |
Neomycin B exhibits poor antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, while kanamycin A shows weak activity against MRSA, methicillin-resistant Staphylococcus epidermidis (MRSE) and P. aeruginosa. The main purpose of this work was to study whether lipid conjugation of guanidinylated neomycin B- and kanamycin A-derived cationic headgroups could restore antibacterial activity against neomycin B- and kanamycin A-resistant strains, while retaining antibacterial activity against non-resistant strains.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1460-2091
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1224-7
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pubmed:meshHeading |
pubmed-meshheading:20332193-Anti-Bacterial Agents,
pubmed-meshheading:20332193-Bacterial Infections,
pubmed-meshheading:20332193-Framycetin,
pubmed-meshheading:20332193-Gram-Negative Bacteria,
pubmed-meshheading:20332193-Gram-Positive Bacteria,
pubmed-meshheading:20332193-Guanidines,
pubmed-meshheading:20332193-Humans,
pubmed-meshheading:20332193-Kanamycin,
pubmed-meshheading:20332193-Lipids,
pubmed-meshheading:20332193-Microbial Sensitivity Tests,
pubmed-meshheading:20332193-Molecular Structure
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pubmed:year |
2010
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pubmed:articleTitle |
Antibacterial activity of guanidinylated neomycin B- and kanamycin A-derived amphiphilic lipid conjugates.
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pubmed:affiliation |
Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, R3T 2N2 Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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