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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1991-6-26
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pubmed:abstractText |
Preparation of cephalosporins bearing a 1,3-dithietane ring attached to the C-3 position using intramolecular rearrangement are described. The diastereoisomers (6a-I and 6a-II) were separated by silica gel column chromatography. These 3-[4-(carbamoyl carboxymethylene)-1,3-dithietane-2-yl]cephems showed comparable activity against Gram-negative bacteria to that of ceftazidime.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0021-8820
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
415-21
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2032950-Cephalosporins,
pubmed-meshheading:2032950-Chemical Phenomena,
pubmed-meshheading:2032950-Chemistry,
pubmed-meshheading:2032950-Gram-Negative Bacteria,
pubmed-meshheading:2032950-Molecular Structure,
pubmed-meshheading:2032950-Stereoisomerism,
pubmed-meshheading:2032950-Structure-Activity Relationship
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pubmed:year |
1991
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pubmed:articleTitle |
Studies on beta-lactam antibiotics. II. Synthesis and antibacterial activity of cephalosporins with substituted 1,3-dithietane directly attached to the C-3 position.
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pubmed:affiliation |
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Ibaraki, Japan.
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pubmed:publicationType |
Journal Article
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