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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3-4
|
| pubmed:dateCreated |
1991-6-20
|
| pubmed:abstractText |
In five head-injured patients with cerebral contusion and oedema in whom it was not possible to control intracranial pressure (ICP) (ICP greater than 20 mmHg) by artificial hyperventilation (PaCO2 level 3.5-4.0 kPa) and barbiturate sedation, indomethacin was used as a vasoconstrictor drug. In all patients, indomethacin (a bolus injection of 30 mg, followed by 30 mg/h for seven hours) reduced ICP below 20 mmHg for several hours. Studies of cerebral circulation and metabolism during indomethacin treatment showed a decrease in CBF at 2 h. After 7 h, ICP remained below 20 mmHg in three patients, and these still had reduced CBF. In the other patients a return of ICP and CBF to pretreatment levels was observed. In all patients indomethacin treatment was followed by a fall in rectal temperature. These results suggest that indomethacin due to its cerebral vasoconstrictor and antipyretic effect should be considered as an alternative for treatment of ICP-hypertension in head-injured patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0001-6268
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
108
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
116-21
|
| pubmed:dateRevised |
2009-11-11
|
| pubmed:meshHeading |
pubmed-meshheading:2031471-Adult,
pubmed-meshheading:2031471-Blood Flow Velocity,
pubmed-meshheading:2031471-Blood Pressure,
pubmed-meshheading:2031471-Body Temperature,
pubmed-meshheading:2031471-Brain,
pubmed-meshheading:2031471-Brain Injuries,
pubmed-meshheading:2031471-Cerebrovascular Circulation,
pubmed-meshheading:2031471-Energy Metabolism,
pubmed-meshheading:2031471-Glasgow Coma Scale,
pubmed-meshheading:2031471-Humans,
pubmed-meshheading:2031471-Indomethacin,
pubmed-meshheading:2031471-Infusions, Intravenous,
pubmed-meshheading:2031471-Intracranial Pressure,
pubmed-meshheading:2031471-Lactates,
pubmed-meshheading:2031471-Lactic Acid,
pubmed-meshheading:2031471-Male,
pubmed-meshheading:2031471-Oxygen,
pubmed-meshheading:2031471-Pseudotumor Cerebri
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
The effects of indomethacin on intracranial pressure, cerebral blood flow and cerebral metabolism in patients with severe head injury and intracranial hypertension.
|
| pubmed:affiliation |
Department of Neuroanaesthesia, Arhus Kommunehospital, Denmark.
|
| pubmed:publicationType |
Journal Article
|