|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2010-7-12
|
|
pubmed:abstractText |
Previous studies have revealed a phosphatase and tensin homolog (PTEN)-dependent interaction between the sphingolipid agonist dihydrosphingosine 1-phosphate (dhS1P) and the transforming growth factor beta/Smad3 signaling pathway. This study was undertaken to examine responses of systemic sclerosis (SSc) fibroblasts to sphingosine 1-phosphate (S1P) and dhS1P and to gain further insight into the regulation of the S1P/dhS1P/PTEN pathway in SSc fibrosis.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-12847691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-12875977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-14576666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-15192102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-15247277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-15485866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-15675946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-16179636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-16278291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-16299553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-16319104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-16322555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-17200201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-17332883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-17641298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-17971005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-18032782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-18323784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-18329536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-18482992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-18552276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-18668558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-18668566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-19114990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-19228708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-19521548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-19543271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309867-7378088
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1529-0131
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
62
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2117-26
|
|
pubmed:dateRevised |
2011-8-1
|
|
pubmed:meshHeading |
pubmed-meshheading:20309867-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:20309867-Cells, Cultured,
pubmed-meshheading:20309867-Female,
pubmed-meshheading:20309867-Fibroblasts,
pubmed-meshheading:20309867-Humans,
pubmed-meshheading:20309867-Male,
pubmed-meshheading:20309867-PTEN Phosphohydrolase,
pubmed-meshheading:20309867-Scleroderma, Systemic,
pubmed-meshheading:20309867-Signal Transduction,
pubmed-meshheading:20309867-Sphingosine,
pubmed-meshheading:20309867-Up-Regulation
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels.
|
|
pubmed:affiliation |
Medical University of South Carolina, Charleston, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
