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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-10-18
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pubmed:abstractText |
The incomplete penetrance of mutations in BRCA1 and BRCA2 suggests that some combination of environmental and genetic factors modifies the risk of breast cancer in mutation carriers. This study sought to identify possible interactions between established breast cancer risk factors and BRCA1 or BRCA2 mutations using a case-only study design. Breast cancer cases that had been tested for BRCA1 and BRCA2 mutations were identified from 11 collaborating centers. Comparisons of reproductive and lifestyle risk factors were made between women with breast cancer who were positive for BRCA1 mutations (n = 283), BRCA2 mutations (n = 204), or negative for both BRCA1 and BRCA2 mutations (n = 894). Interaction risk ratios (IRRs) were calculated using multinominal logistic regression models. Compared with non-carriers, statistically significant IRRs were observed for later age at menarche among BRCA2 mutation carriers, for a greater number of pregnancies among both BRCA1 and BRCA2 mutation carriers, and for alcohol use among BRCA1 mutation carriers. Our data suggest that the risk for breast cancer among BRCA1 or BRCA2 carriers may be modified by reproductive characteristics and alcohol use. However, our results should be interpreted cautiously given the overall inconsistency in the epidemiologic literature on modifiers of BRCA1 and BRCA2.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1573-7217
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pubmed:author |
pubmed-author:ArunBanuB,
pubmed-author:BrzosowiczJenniferJ,
pubmed-author:DomchekSusan MSM,
pubmed-author:FinkelsteinDianne MDM,
pubmed-author:GarberJudy EJE,
pubmed-author:GriffinConstance ACA,
pubmed-author:GruberStephenS,
pubmed-author:IsaacsClaudineC,
pubmed-author:IversenEdwin SES,
pubmed-author:Kathleen Cuningham Consortium for Research into Familial Breast Cancer,
pubmed-author:LeeEunjungE,
pubmed-author:MarcomP KellyPK,
pubmed-author:MarksJeffrey RJR,
pubmed-author:MoormanPatricia GPG,
pubmed-author:RebbeckTimothy RTR,
pubmed-author:SchildkrautJoellen MJM,
pubmed-author:SussweinLisaL,
pubmed-author:SutphenRebeccaR,
pubmed-author:UrsinGiskeG,
pubmed-author:VisvanathanKalaK,
pubmed-author:WangFrancesF
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pubmed:issnType |
Electronic
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
441-51
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20309627-Adolescent,
pubmed-meshheading:20309627-Adult,
pubmed-meshheading:20309627-Age Factors,
pubmed-meshheading:20309627-Alcohol Drinking,
pubmed-meshheading:20309627-BRCA1 Protein,
pubmed-meshheading:20309627-BRCA2 Protein,
pubmed-meshheading:20309627-Breast Neoplasms,
pubmed-meshheading:20309627-Child,
pubmed-meshheading:20309627-DNA Mutational Analysis,
pubmed-meshheading:20309627-Effect Modifier, Epidemiologic,
pubmed-meshheading:20309627-Female,
pubmed-meshheading:20309627-Genetic Predisposition to Disease,
pubmed-meshheading:20309627-Humans,
pubmed-meshheading:20309627-Linear Models,
pubmed-meshheading:20309627-Logistic Models,
pubmed-meshheading:20309627-Menarche,
pubmed-meshheading:20309627-Middle Aged,
pubmed-meshheading:20309627-Mutation,
pubmed-meshheading:20309627-Odds Ratio,
pubmed-meshheading:20309627-Parity,
pubmed-meshheading:20309627-Phenotype,
pubmed-meshheading:20309627-Pregnancy,
pubmed-meshheading:20309627-Risk Assessment,
pubmed-meshheading:20309627-Risk Factors,
pubmed-meshheading:20309627-United States,
pubmed-meshheading:20309627-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis.
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pubmed:affiliation |
Cancer Prevention Detection and Control Research Program, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27705, USA. patricia.moorman@duke.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Multicenter Study,
Research Support, N.I.H., Extramural
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