Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-3-23
pubmed:abstractText
We analyzed morphological and immunohistochemical features in 174 aggressive B-cell lymphomas of nodal and extranodal origin. Morphological features included presence or absence of a follicular component and cytologic criteria according to the Kiel classification, whereas immunohistochemical studies included expression of CD10, BCL-2, BCL-6, IRF4/MUM1, HLA-DR, p53, Ki-67 and the assessment of plasmacytoid differentiation. Patients were treated with a CHOP-like regimen. While the presence or absence of either CD10, BCL-6 and IRF4/MUM1 reactivity or plasmacytoid differentiation did not identify particular cytomorphologic or site-specific subtypes, we found that expression of CD10 and BCL-6, and a low reactivity for IRF4/MUM1 were favourable prognostic indicators. In contrast, BCL-2 expression and presence of a monotypic cytoplasmic immunoglobulin expression was associated with an unfavourable prognosis in univariate analyses. Meta-analysis of these data resulted in the development of a cumulative immunohistochemical outcome predictor score (CIOPS) enabling the recognition of four distinct prognostic groups. Multivariate analysis proved this score to be independent of the international prognostic index. Such a cumulative immunohistochemical scoring approach might provide a valuable alternative in the recognition of defined risk types of aggressive B-cell lymphomas.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-10089896, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-10556197, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-10676951, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-10706878, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-10843287, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-11293907, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-11488064, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-11493437, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-11781220, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-11786909, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-11830458, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-11895902, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-11908742, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-11960356, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-11986240, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-12075054, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-12131154, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-12393466, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-14504078, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-14603341, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-14976040, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-15720419, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-15749666, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-15920553, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-16129841, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-16400625, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-16670073, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-16943530, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-17149956, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-17299093, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-17327602, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-17986209, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-18086797, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-18794197, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-19038878, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-3281723, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-3285208, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-8208268, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-8547651, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-8683246, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-8704213, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-9002964, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-9116271, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-9207459, http://linkedlifedata.com/resource/pubmed/commentcorrection/20309427-9787151
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:issn
1865-5785
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
187-94
pubmed:year
2009
pubmed:articleTitle
A cytomorphological and immunohistochemical profile of aggressive B-cell lymphoma: high clinical impact of a cumulative immunohistochemical outcome predictor score.
pubmed:publicationType
Journal Article