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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1991-6-18
|
| pubmed:databankReference | |
| pubmed:abstractText |
The murine Cas NS-1 retrovirus carries the v-cbl oncogene and induces pre-B cell lymphomas and myeloid leukemias. The cellular homolog of v-cbl has been identified in mouse and human DNA, and was recently mapped to mouse chromosome 9 and human chromosome 11q23. To determine the coding sequences of the human and mouse c-cbl proto-oncogenes cDNA clones were isolated from libraries prepared from the human T cell leukemia lines CCRF-CEM and HUT 78, and the mouse pre-B cell line 70Z/3. DNA sequencing revealed an open reading frame encoding 906 amino acids in the human cDNAs and 896 amino acids in 70Z/3. The sequence showed that v-cbl is a markedly truncated form of murine c-cbl containing 355 N-terminal amino acids. The nucleotide sequence of v-cbl is identical to murine c-cbl in this region, and the human sequence has only five amino acid changes in the v-cbl portion. The most notable features of the sequence which was lost in the generation of v-cbl is a C-terminal leucine zipper and a stretch of 208 amino acids containing 23% proline and 19% serine/threonine residues. This proline-rich sequence has similarities to the transcriptional activation domains of some transcription factors, and v-cbl's transforming potential may be due to the loss of this region and the leucine zipper.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CBL protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Protein v-cbl,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-cbl,
http://linkedlifedata.com/resource/pubmed/chemical/Retroviridae Proteins, Oncogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0950-9232
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
653-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2030914-Amino Acid Sequence,
pubmed-meshheading:2030914-Animals,
pubmed-meshheading:2030914-Base Sequence,
pubmed-meshheading:2030914-Chromosomes, Human, Pair 11,
pubmed-meshheading:2030914-Cloning, Molecular,
pubmed-meshheading:2030914-Gene Library,
pubmed-meshheading:2030914-Humans,
pubmed-meshheading:2030914-Leucine Zippers,
pubmed-meshheading:2030914-Mice,
pubmed-meshheading:2030914-Molecular Sequence Data,
pubmed-meshheading:2030914-Oncogene Protein v-cbl,
pubmed-meshheading:2030914-Open Reading Frames,
pubmed-meshheading:2030914-Proto-Oncogene Proteins,
pubmed-meshheading:2030914-Proto-Oncogene Proteins c-cbl,
pubmed-meshheading:2030914-Restriction Mapping,
pubmed-meshheading:2030914-Retroviridae Proteins, Oncogenic,
pubmed-meshheading:2030914-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2030914-Transformation, Genetic,
pubmed-meshheading:2030914-Ubiquitin-Protein Ligases
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.
|
| pubmed:affiliation |
Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, Australia.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|