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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-4-13
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pubmed:abstractText |
Peripheral immune tolerance is generally thought to result from cross-presentation of tissue-derived proteins by quiescent tissue-resident dendritic cells to self-reactive T cells that have escaped thymic negative selection, leading to anergy or deletion. Recently, we and others have implicated the lymph node (LN) stroma in mediating CD8 T cell peripheral tolerance. We demonstrate that LN-resident lymphatic endothelial cells express multiple peripheral tissue antigens (PTAs) independent of the autoimmune regulator (Aire). They directly present an epitope derived from one of these, the melanocyte-specific protein tyrosinase, to tyrosinase-specific CD8 T cells, leading to their deletion. We also show that other LN stromal subpopulations express distinct PTAs by mechanisms that vary in their Aire dependence. These results establish lymphatic endothelial cells, and potentially other LN-resident cells, as systemic mediators of peripheral immune tolerance.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/APECED protein,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD31,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamate Decarboxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Gp38 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Gpa33 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/MART-1 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mlana protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Monophenol Monooxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate decarboxylase 1
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1540-9538
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
12
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pubmed:volume |
207
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
681-8
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pubmed:dateRevised |
2011-10-31
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pubmed:meshHeading |
pubmed-meshheading:20308365-Animals,
pubmed-meshheading:20308365-Antigen Presentation,
pubmed-meshheading:20308365-Antigens, CD31,
pubmed-meshheading:20308365-Antigens, Neoplasm,
pubmed-meshheading:20308365-Autoantigens,
pubmed-meshheading:20308365-Cell Proliferation,
pubmed-meshheading:20308365-Endothelial Cells,
pubmed-meshheading:20308365-Epitopes, T-Lymphocyte,
pubmed-meshheading:20308365-Gene Expression,
pubmed-meshheading:20308365-Glutamate Decarboxylase,
pubmed-meshheading:20308365-Histocompatibility Antigens Class I,
pubmed-meshheading:20308365-Immune Tolerance,
pubmed-meshheading:20308365-Immunophenotyping,
pubmed-meshheading:20308365-Lymph Nodes,
pubmed-meshheading:20308365-Lymphocyte Activation,
pubmed-meshheading:20308365-MART-1 Antigen,
pubmed-meshheading:20308365-Membrane Glycoproteins,
pubmed-meshheading:20308365-Mice,
pubmed-meshheading:20308365-Mice, Inbred BALB C,
pubmed-meshheading:20308365-Mice, Knockout,
pubmed-meshheading:20308365-Mice, Transgenic,
pubmed-meshheading:20308365-Monophenol Monooxygenase,
pubmed-meshheading:20308365-Neoplasm Proteins,
pubmed-meshheading:20308365-Receptors, Antigen, T-Cell,
pubmed-meshheading:20308365-Stromal Cells,
pubmed-meshheading:20308365-T-Lymphocytes,
pubmed-meshheading:20308365-Transcription Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation.
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pubmed:affiliation |
Department of Microbiology and Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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