Linked Life Data

20307692

Source:http://linkedlifedata.com/resource/pubmed/id/20307692

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-5-24
pubmed:abstractText
Polyglutamine tract-binding protein-1 (PQBP-1) is a nuclear protein that interacts with various proteins, including RNA polymerase II and the spliceosomal protein U5-15kD. PQBP-1 is known to be associated with X-linked mental retardation in which a frameshift mutation in the PQBP-1 gene occurs. In the present study, we demonstrate that PQBP-1 binds to U5-15kD via a continuous 23-residue segment within its C-terminal domain. Intriguingly, this segment is lost in the frameshift mutants of PQBP-1 associated with X-linked mental retardation. These findings suggest that the frameshift mutations in the PQBP-1 gene lead to expression of mutants lacking the ability to interact with U5-15kD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-3002
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Print
pubmed:volume
1804
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1500-7
pubmed:meshHeading
pubmed-meshheading:20307692-Amino Acid Sequence, pubmed-meshheading:20307692-Carrier Proteins, pubmed-meshheading:20307692-Frameshift Mutation, pubmed-meshheading:20307692-Glutathione Transferase, pubmed-meshheading:20307692-Humans, pubmed-meshheading:20307692-Kinetics, pubmed-meshheading:20307692-Magnetic Resonance Spectroscopy, pubmed-meshheading:20307692-Molecular Conformation, pubmed-meshheading:20307692-Molecular Sequence Data, pubmed-meshheading:20307692-Nuclear Proteins, pubmed-meshheading:20307692-Protein Binding, pubmed-meshheading:20307692-Protein Structure, Tertiary, pubmed-meshheading:20307692-RNA Polymerase II, pubmed-meshheading:20307692-Recombinant Proteins, pubmed-meshheading:20307692-Ribonucleoprotein, U5 Small Nuclear, pubmed-meshheading:20307692-Sequence Homology, Amino Acid, pubmed-meshheading:20307692-Spliceosomes
pubmed:year
2010
pubmed:articleTitle
Polyglutamine tract-binding protein-1 binds to U5-15kD via a continuous 23-residue segment of the C-terminal domain.
pubmed:affiliation
Faculty of Pharmaceutical Sciences, University of Toyama, 2630, Sugitani, Toyama 930-0194, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't