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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2010-4-7
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pubmed:abstractText |
In this communication, we describe the successful encapsulation of (177)Lu into the endohedral metallofullerene (177)Lu(x)Lu(3-x)N@C(80) (x = 1-3) starting with (177)LuCl(3) in a modified quartz Kraschmer-Huffman electric generator. We demonstrate that the (177)Lu (beta-emitter) in this fullerene cage is not significantly released for a period of up to at least one-half-life (6.7 days). We also demonstrate that this agent can be conjugated with an interleukin-13 peptide that is designed to target an overexpressed receptor in glioblastoma multiforme tumors. This nanoparticle delivery platform provides flexibility for a wide range of radiotherapeutic and radiodiagnostic multimodal applications.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1520-5126
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pubmed:author |
pubmed-author:DornHarry CHC,
pubmed-author:DuchampJames CJC,
pubmed-author:FatourosPanos PPP,
pubmed-author:FillmoreHelen LHL,
pubmed-author:GeJiechaoJ,
pubmed-author:GibsonHarry WHW,
pubmed-author:HirschJerry IJI,
pubmed-author:ShuChun-YingCY,
pubmed-author:ShultzMichael DMD,
pubmed-author:WilsonJohn DJD,
pubmed-author:ZhangJianyuanJ
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pubmed:issnType |
Electronic
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pubmed:day |
14
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4980-1
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
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pubmed:year |
2010
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pubmed:articleTitle |
Encapsulation of a radiolabeled cluster inside a fullerene cage, (177)Lu(x)Lu((3-x))N@C(80): an interleukin-13-conjugated radiolabeled metallofullerene platform.
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pubmed:affiliation |
Department of Radiology, Virginia Commonwealth University, Richmond, Virginia 23298, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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