Linked Life Data

20306664

Source:http://linkedlifedata.com/resource/pubmed/id/20306664

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-3-23
pubmed:abstractText
The present study aimed to analyze the role of interleukin-1beta (IL-1beta) and nitric oxide (NO) in the development of peripheral acute inflammation in carrageenan-induced paw edema model in the presence/absence of acetyl salicylic acid (ASA). A 0.5 ml solution of 0.5%, 1% and 2% carrageenan was administered intraplantarly in right hind paw of adult Swiss mice. ASA was administered in a single dose of 200 mg/kg 1 hour before intraplantar injection of carrageenan. Paw volume, IL-1beta and nitrite levels in plasma and paw infiltrate and the total and differential white blood cells count were determined. Carrageenan administration induced a dose-dependent increase in paw volume, IL-1beta level in paw infiltrate and nitrite content in plasma. ASA exhibited a better anti-inflammatory effect where 2% carrageenan was used as the inflammatory agent. Pre-treatment with ASA resulted in increase in plasma IL-1beta level, decrease in IL-1beta level at the inflammation site and restoring plasma nitrite concentration to its normal range. Our results stressed on the role of IL-1beta and NO in the acute inflammation and suggested that the dose of carrageenan is the major determinant in the response to ASA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1110-4902
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-33
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Role of interleukin-1beta and nitric oxide in the antiinflammatory dynamics of acetylsalicylic acid in carrageenan-induced paw oedema model.
pubmed:affiliation
National Organization for Drug Control and Research, Agouza, Cairo, Egypt.
pubmed:publicationType
Journal Article