Linked Life Data

20306476

Source:http://linkedlifedata.com/resource/pubmed/id/20306476

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-8-10
pubmed:databankReference
pubmed:abstractText
Vitamin D is the critical hormone for intestinal absorption of calcium. Optimal calcium absorption is important for proper mineralization of bone in the prevention of osteoporosis and osteoporotic fractures, among other important functions. Diseases associated with gut inflammation, such as Crohn's disease (CD), may impair calcium absorption. This pilot study evaluated vitamin D- dependent calcium absorption in subjects with CD. Male subjects with CD (n=4) and healthy age-matched controls (n=5) were studied. All subjects had fractional calcium absorption (FCA; by the dual calcium isotope method), serum 25-hydroxyvitamin D, serum calcium and 24 h urinary calcium excretion measurements at baseline. The FCA in response to vitamin D therapy was re-assessed following administration of oral calcitriol 0.25 mcg twice daily for 1 wk, followed by oral calcitriol 0.50 mcg twice daily for 1 wk. Serum calcium and 24 h urinary calcium determinations were re-assessed after each increasing dose of calcitriol as safety measures. There was no significant difference in calcium FCA at baseline or after increasing doses of calcitriol between the CD and controls. FCA in the control and CD group was approximately 35% at baseline, which increased to 60% after calcitriol therapy. No subject developed hypercalcemia or hypercalciuria. Our results suggest that CD patients have a normal response to vitamin D in enhancing the efficacy of calcium absorption. This suggests that stable CD patients can follow calcium and vitamin D guidelines of non-CD adults. Other factors independent of vitamin D status may impair intestinal calcium absorption in CD, including the degree and location of inflammation, presence of surgical resection and/or use of glucocorticoids.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1613-4133
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1085-91
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed-meshheading:20306476-25-Hydroxyvitamin D 2, pubmed-meshheading:20306476-Adult, pubmed-meshheading:20306476-Calcifediol, pubmed-meshheading:20306476-Calcitriol, pubmed-meshheading:20306476-Calcium, pubmed-meshheading:20306476-Calcium, Dietary, pubmed-meshheading:20306476-Calcium Isotopes, pubmed-meshheading:20306476-Case-Control Studies, pubmed-meshheading:20306476-Crohn Disease, pubmed-meshheading:20306476-Diet, pubmed-meshheading:20306476-Dietary Supplements, pubmed-meshheading:20306476-Humans, pubmed-meshheading:20306476-Intestinal Absorption, pubmed-meshheading:20306476-Male, pubmed-meshheading:20306476-Middle Aged, pubmed-meshheading:20306476-Nutritional Requirements, pubmed-meshheading:20306476-Pilot Projects, pubmed-meshheading:20306476-Questionnaires, pubmed-meshheading:20306476-Severity of Illness Index, pubmed-meshheading:20306476-Tumor Necrosis Factor-alpha
pubmed:year
2010
pubmed:articleTitle
Vitamin D-mediated calcium absorption in patients with clinically stable Crohn's disease: a pilot study.
pubmed:affiliation
Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
pubmed:publicationType
Journal Article, Controlled Clinical Trial, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural