rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-4-5
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pubmed:abstractText |
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase is being pursued with the assistance of free energy perturbation (FEP) calculations to predict relative free energies of binding. Extension of azole-containing inhibitors into an 'eastern' channel between Phe227 and Pro236 has led to the discovery of potent and structurally novel derivatives.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AI44616,
http://linkedlifedata.com/resource/pubmed/grant/GM32136,
http://linkedlifedata.com/resource/pubmed/grant/GM49551,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI044616-11S1,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI044616-12,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI044616-13,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI044616-14,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM032136-27,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM032136-27S1,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM049551-16A2,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM049551-17,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM049551-19
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-11481007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-11850281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-12296734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-1377403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-15658855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-15743172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-15870211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-16200637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-16263277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-16302798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-17918923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-18588301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-19317443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-19778066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-7513427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20304641-8304960
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2485-8
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pubmed:dateRevised |
2011-10-31
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pubmed:meshHeading |
|
pubmed:year |
2010
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pubmed:articleTitle |
Eastern extension of azoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase; cyano group alternatives.
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pubmed:affiliation |
Department of Chemistry, Yale University, New Haven, CT 06520, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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