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pubmed-article:20300596pubmed:abstractTextDepression is an independent risk factor for cardiovascular diseases and is associated with metabolic syndrome (MetS). Levels of plasminogen activator inhibitor-1 (PAI-1), an inhibitor of tissue-type and urokinase-type plasminogen activators, are associated with MetS. To clarify the role of PAI-1 in subjects with long-term adverse mental symptomatology (LMS; including depression) and MetS, we measured circulating PAI-1 levels in controls (n = 111), in subjects with MetS and free of mental symptoms (n = 42), and in subjects with both MetS and long-term mental symptoms (n = 70). PAI-1 increased linearly across the three groups in men. In logistic regression analysis, men with PAI-1 levels above the median had a 3.4-fold increased likelihood of suffering from the comorbidity of long-term adverse mental symptoms and MetS, while no such associations were detected in women. In conclusion, our results suggest that in men high PAI-1 levels are independently associated with long-term mental symptomatology.lld:pubmed
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pubmed-article:20300596pubmed:issn2090-0171lld:pubmed
pubmed-article:20300596pubmed:authorpubmed-author:NiskanenLeoLlld:pubmed
pubmed-article:20300596pubmed:authorpubmed-author:ViinamäkiHeim...lld:pubmed
pubmed-article:20300596pubmed:authorpubmed-author:HintikkaJukka...lld:pubmed
pubmed-article:20300596pubmed:authorpubmed-author:HonkalampiKir...lld:pubmed
pubmed-article:20300596pubmed:authorpubmed-author:Koivumaa-Honk...lld:pubmed
pubmed-article:20300596pubmed:authorpubmed-author:HerzigKarl-He...lld:pubmed
pubmed-article:20300596pubmed:authorpubmed-author:TolmunenTommi...lld:pubmed
pubmed-article:20300596pubmed:authorpubmed-author:HuotariAnneAlld:pubmed
pubmed-article:20300596pubmed:authorpubmed-author:LehtoSoili...lld:pubmed
pubmed-article:20300596pubmed:authorpubmed-author:KaikkonenNoor...lld:pubmed
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pubmed-article:20300596pubmed:pagination501349lld:pubmed
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pubmed-article:20300596pubmed:articleTitleIncreased Serum PAI-1 Levels in Subjects with Metabolic Syndrome and Long-Term Adverse Mental Symptoms: A Population-Based Study.lld:pubmed
pubmed-article:20300596pubmed:affiliationDivision of Physiology, Institute of Biomedicine, Biocenter Oulu, University of Oulu, 90014 Oulu, Finland.lld:pubmed
pubmed-article:20300596pubmed:publicationTypeJournal Articlelld:pubmed