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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-7-16
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pubmed:abstractText |
Cardiac mineralocorticoid receptor (MR) activation triggers adverse cardiovascular events that could be efficiently prevented by mineralocorticoid antagonists. To gain insights into the pathophysiological role of MR function, we established embryonic stem (ES) cell lines from blastocysts of transgenic mice overexpressing the human MR driven by its proximal P1 or distal P2 promoter and presenting with cardiomyopathy, tachycardia, and arrhythmia. Cardiomyocyte differentiation allowed us to investigate the molecular mechanisms contributing to MR-mediated cardiac dysfunction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aldosterone Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels, L-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Cav1.2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide-Gated Cation...,
http://linkedlifedata.com/resource/pubmed/chemical/HCN3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/KCNJ2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Inwardly...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Mineralocorticoid,
http://linkedlifedata.com/resource/pubmed/chemical/Spironolactone,
http://linkedlifedata.com/resource/pubmed/chemical/hyperpolarization-activated cation...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
467-75
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pubmed:meshHeading |
pubmed-meshheading:20299331-Aldosterone Antagonists,
pubmed-meshheading:20299331-Animals,
pubmed-meshheading:20299331-Calcium Channels, L-Type,
pubmed-meshheading:20299331-Cell Differentiation,
pubmed-meshheading:20299331-Cell Line,
pubmed-meshheading:20299331-Cyclic Nucleotide-Gated Cation Channels,
pubmed-meshheading:20299331-Embryonic Stem Cells,
pubmed-meshheading:20299331-Heart Rate,
pubmed-meshheading:20299331-Humans,
pubmed-meshheading:20299331-Membrane Potentials,
pubmed-meshheading:20299331-Mice,
pubmed-meshheading:20299331-Mice, Transgenic,
pubmed-meshheading:20299331-Myocardial Contraction,
pubmed-meshheading:20299331-Myocytes, Cardiac,
pubmed-meshheading:20299331-Potassium Channels,
pubmed-meshheading:20299331-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:20299331-RNA, Messenger,
pubmed-meshheading:20299331-Receptors, Mineralocorticoid,
pubmed-meshheading:20299331-Spironolactone,
pubmed-meshheading:20299331-Time Factors,
pubmed-meshheading:20299331-Up-Regulation
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pubmed:year |
2010
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pubmed:articleTitle |
Mineralocorticoid receptor overexpression in embryonic stem cell-derived cardiomyocytes increases their beating frequency.
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pubmed:affiliation |
INSERM U693, Faculté de Médecine Paris-Sud, 63, rue Gabriel Péri, 94276 Le Kremlin Bicêtre Cedex, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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