Source:http://linkedlifedata.com/resource/pubmed/id/20299220
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2010-4-5
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| pubmed:abstractText |
4,7-Dichloro-1-benzothien-2-yl sulfonylaminomethyl boronic acid (DSABA, Compound I) was discovered as the first boronic acid-based class D beta-lactamase inhibitor. It exhibited an IC(50) of 5.6 microM against OXA-40. The compound also inhibited class A and C beta-lactamases with sub to low microM IC(50), and synergized with imipenem against Acinetobacter baumannii.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1464-3405
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
15
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| pubmed:volume |
20
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2622-4
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| pubmed:meshHeading |
pubmed-meshheading:20299220-Acinetobacter baumannii,
pubmed-meshheading:20299220-Anti-Bacterial Agents,
pubmed-meshheading:20299220-Boronic Acids,
pubmed-meshheading:20299220-Enzyme Inhibitors,
pubmed-meshheading:20299220-Inhibitory Concentration 50,
pubmed-meshheading:20299220-Microbial Sensitivity Tests,
pubmed-meshheading:20299220-beta-Lactamases
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| pubmed:year |
2010
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| pubmed:articleTitle |
4,7-Dichloro benzothien-2-yl sulfonylaminomethyl boronic acid: first boronic acid-derived beta-lactamase inhibitor with class A, C, and D activity.
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| pubmed:affiliation |
Department of Medicinal Chemistry, Merck & Co., Inc., Rahway, NJ 07065, USA. qiang_tan@merck.com
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| pubmed:publicationType |
Journal Article
|