Linked Life Data

20299172

Source:http://linkedlifedata.com/resource/pubmed/id/20299172

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-12-6
pubmed:abstractText
In diffusion-weighted magnetic resonance imaging (DWI), the intensity of the acquired magnetic resonance signal depends on the self-diffusion of the excited spins, i.e., on the microscopic stochastic Brownian molecular motion. Since the extent and orientation of molecular motion is influenced by the microscopic structure and organization of biological tissues, DWI can depict various pathological changes of organs or tissues. While DWI of the brain can be considered an established technique since the mid-1990s, significantly fewer studies have been published about DWI in body imaging, mainly because of the relatively low robustness of conventional DWI methods in non-neurological applications. Consequently, the image quality in such applications was rather limited. This situation, however, improved considerably in recent years due to better hardware as well as new pulse sequences, and several new applications of DWI (e.g., in the abdominal organs, in musculoskeletal applications, or in whole-body protocols) have been described. Unfortunately, DWI of the body is complicated by frequently low signal-to-noise ratios due to shorter transversal (T2) relaxation times and by strong variations of susceptibility. The latter result in severe distortion artifacts when standard echo-planar DWI techniques are applied. Hence, several alternative (non-echo-planar) diffusion-weighting pulse sequence types were proposed and evaluated for DWI applications in the body. In this review article, first the basics of molecular diffusion and of diffusion-weighted MRI are introduced and then several specific MRI techniques, which have been used for DWI of the body, are described. Finally, protocol recommendations for different DWI applications in the body are provided.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1872-7727
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
314-22
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Technical aspects of MR diffusion imaging of the body.
pubmed:affiliation
Josef Lissner Laboratory for Biomedical Imaging, Department of Clinical Radiology - Grosshadern, LMU Ludwig Maximilian University of Munich, Marchioninistr. 15, 81377 Munich, Germany. od@dtrx.net
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't