Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-5-3
pubmed:abstractText
The Tubby mouse is a phenotypic model for sensorineural deafness and retinal dystrophy including Usher syndrome type 1. Thioredoxin is a small 13kDa protein which, when ubiquitously expressed as a transgene in the mouse, provides protection against multiple disease states including light-induced and oxidative stress-induced neurodegeneration and is down-regulated in the Tubby retina. We tested if overexpression of human thioredoxin in the Tubby mouse inhibits retinal degeneration and loss of visual function. Electroretinography, immunocytochemistry, quantitative histology, RT-PCR and Western blots were used to obtain data which showed that thioredoxin overexpression prevented loss of photoreceptors and retinal function. Analysis of signal pathways showed that thioredoxin up-regulated neurotrophic factors BDNF and GDNF and activated survival signaling pathways Akt, Ras/Raf1/ and the ERKs while inhibiting the ASK1/JNK apoptosis pathway. Relationships between the Tubby gene, its pathological phenotype and regulation of the thioredoxin system remain to be established.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/COBRE/CORE P20 RR17703, http://linkedlifedata.com/resource/pubmed/grant/EY014427, http://linkedlifedata.com/resource/pubmed/grant/NEI/CORE P30- EY12190, http://linkedlifedata.com/resource/pubmed/grant/P20 RR017703-039003, http://linkedlifedata.com/resource/pubmed/grant/P20 RR017703-049003, http://linkedlifedata.com/resource/pubmed/grant/P20 RR017703-057333, http://linkedlifedata.com/resource/pubmed/grant/P20 RR017703-067514, http://linkedlifedata.com/resource/pubmed/grant/P20 RR017703-076665, http://linkedlifedata.com/resource/pubmed/grant/P20 RR017703-086147, http://linkedlifedata.com/resource/pubmed/grant/P30 EY012190-01A19001, http://linkedlifedata.com/resource/pubmed/grant/P30 EY012190-029001, http://linkedlifedata.com/resource/pubmed/grant/P30 EY012190-039001, http://linkedlifedata.com/resource/pubmed/grant/P30 EY012190-049001, http://linkedlifedata.com/resource/pubmed/grant/P30 EY012190-059001, http://linkedlifedata.com/resource/pubmed/grant/P30 EY012190-079001, http://linkedlifedata.com/resource/pubmed/grant/P30 EY012190-089001, http://linkedlifedata.com/resource/pubmed/grant/P30 EY012190-099001, http://linkedlifedata.com/resource/pubmed/grant/P30 EY012190-109001, http://linkedlifedata.com/resource/pubmed/grant/R01 EY018724-01A1, http://linkedlifedata.com/resource/pubmed/grant/R01 EY018724-02, http://linkedlifedata.com/resource/pubmed/grant/R01EY018724, http://linkedlifedata.com/resource/pubmed/grant/R21 EY018306-01, http://linkedlifedata.com/resource/pubmed/grant/R21 EY018306-02, http://linkedlifedata.com/resource/pubmed/grant/R21 EY018306-03, http://linkedlifedata.com/resource/pubmed/grant/R21EY018306
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-10097175, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-10488136, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-10740224, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-11032742, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-11266364, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-11381073, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-11923261, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-12057848, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-12076089, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-12391249, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-12533610, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-12724642, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-12742531, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-12788387, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-14711819, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-14713338, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-15181236, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-15610977, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-15728556, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-15731600, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-15985430, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-16216520, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-16311508, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-16322089, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-17073803, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-17115890, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-17360810, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-17394579, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-17443811, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-17512463, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-17562954, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-17602955, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-17654042, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-17949261, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-18256171, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-18441302, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-18586825, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-3896121, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-7547690, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-8041738, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-8473353, http://linkedlifedata.com/resource/pubmed/commentcorrection/20298786-9564042
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1095-953X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
446-55
pubmed:dateRevised
2011-7-28
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