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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
1991-6-19
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pubmed:abstractText |
In 10 patients with previously untreated essential thrombocythemia (ET), by using 111In-labeled platelets and megakaryocyte morphometry, the relation between platelet production rate and bone marrow megakaryocytes was evaluated before and during alpha-2b-interferon (IFN) therapy. A highly significant decrease in platelet count occurred during IFN therapy; the platelet counts, at baseline and after 2 and 6 months of IFN therapy, were 1,102 +/- 345 x 10(9)/L, 524 +/- 169 x 10(9)/L (P less than .0001), and 476 +/- 139 x 10(9)/L (P less than .0001), respectively. The decrement in platelet count was mainly a result of diminished platelet production rate, which at baseline and after 2 and 6 months of IFN therapy was 89 +/- 30 x 10(10) platelets/d, 53 +/- 18 x 10(10) platelets/d (P = .0033), and 45 +/- 20 x 10(10) platelets/d (P less than .0001), respectively. Also, a slight shortening of platelet mean life-span (MLS) was observed in response to IFN treatment; platelet MLS was 7.96 +/- 0.69 days at baseline and 6.68 +/- 1.30 days (P = .012) after 6 months of IFN therapy. IFN induced a significant decrease in bone marrow megakaryocyte volume; both megakaryocyte nuclear and cytoplasmatic volumes were affected. The mean megakaryocyte volume was 372 +/- 126 x 10(2) pL/microL at baseline and 278 +/- 147 x 10(2) pL/microL (P = .049) after 6 months of IFN therapy. However, the number of megakaryocytes did not show any significant change in response to IFN. It is concluded that alpha-IFN reduces platelet production rate and the peripheral platelet count in ET mainly through an anti-proliferative action on the megakaryocytes and to a considerably lesser degree by a shortening of platelet MLS.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-4971
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2103-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2029575-Adult,
pubmed-meshheading:2029575-Aged,
pubmed-meshheading:2029575-Biopsy,
pubmed-meshheading:2029575-Blood Cell Count,
pubmed-meshheading:2029575-Blood Platelets,
pubmed-meshheading:2029575-Bone Marrow Cells,
pubmed-meshheading:2029575-Cell Division,
pubmed-meshheading:2029575-Cell Nucleus,
pubmed-meshheading:2029575-Cytoplasm,
pubmed-meshheading:2029575-Female,
pubmed-meshheading:2029575-Hematopoiesis,
pubmed-meshheading:2029575-Humans,
pubmed-meshheading:2029575-Indium Radioisotopes,
pubmed-meshheading:2029575-Interferon Type I,
pubmed-meshheading:2029575-Male,
pubmed-meshheading:2029575-Megakaryocytes,
pubmed-meshheading:2029575-Middle Aged,
pubmed-meshheading:2029575-Thrombocythemia, Essential
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pubmed:year |
1991
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pubmed:articleTitle |
The effect of alpha-interferon on bone marrow megakaryocytes and platelet production rate in essential thrombocythemia.
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pubmed:affiliation |
Department of Medicine, Ostra Hospital, Gothenburg, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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