| pubmed-article:2027755 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2027755 | lifeskim:mentions | umls-concept:C0016163 | lld:lifeskim |
| pubmed-article:2027755 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:2027755 | lifeskim:mentions | umls-concept:C0022130 | lld:lifeskim |
| pubmed-article:2027755 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:2027755 | pubmed:dateCreated | 1991-6-11 | lld:pubmed |
| pubmed-article:2027755 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2027755 | pubmed:abstractText | In the vertebrate genomes studied to date the 5' end of many genes are associated with distinctive sequences known as CpG islands. CpG islands have three properties: they are non-methylated; the dinucleotide CpG occurs at the frequency predicted by base composition; and they are GC-rich. Unexpectedly we have found that CpG islands in certain fish only have the first two properties; that is, their GC-content is not elevated compared to bulk genomic DNA. Based on this finding, we speculate that the GC-richness of CpG islands in vertebrates other than fish is a passive consequence of a higher mutation rate in regions of open chromatin under conditions where the nucleotide precursor pools are biased. | lld:pubmed |
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| pubmed-article:2027755 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2027755 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2027755 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2027755 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2027755 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2027755 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2027755 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:2027755 | pubmed:author | pubmed-author:CrossSS | lld:pubmed |
| pubmed-article:2027755 | pubmed:author | pubmed-author:SchmidtkeJJ | lld:pubmed |
| pubmed-article:2027755 | pubmed:author | pubmed-author:KovarikPP | lld:pubmed |
| pubmed-article:2027755 | pubmed:author | pubmed-author:BirdAA | lld:pubmed |
| pubmed-article:2027755 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2027755 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:2027755 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:2027755 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2027755 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2027755 | pubmed:pagination | 1469-74 | lld:pubmed |
| pubmed-article:2027755 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2027755 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2027755 | pubmed:articleTitle | Non-methylated islands in fish genomes are GC-poor. | lld:pubmed |
| pubmed-article:2027755 | pubmed:affiliation | Research Institute for Molecular Pathology, Vienna, Austria. | lld:pubmed |
| pubmed-article:2027755 | pubmed:publicationType | Journal Article | lld:pubmed |
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