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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1991-6-11
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pubmed:databankReference |
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pubmed:abstractText |
In the vertebrate genomes studied to date the 5' end of many genes are associated with distinctive sequences known as CpG islands. CpG islands have three properties: they are non-methylated; the dinucleotide CpG occurs at the frequency predicted by base composition; and they are GC-rich. Unexpectedly we have found that CpG islands in certain fish only have the first two properties; that is, their GC-content is not elevated compared to bulk genomic DNA. Based on this finding, we speculate that the GC-richness of CpG islands in vertebrates other than fish is a passive consequence of a higher mutation rate in regions of open chromatin under conditions where the nucleotide precursor pools are biased.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-1974172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-2124275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-2124276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-2317863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-2388851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-2448875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-2762162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-2911369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-3007277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-3023360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-3185557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-355893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-3656447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-3837182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-3915777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-6188105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-6300777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-6322116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-6329026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-6546423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-6585829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2027755-7133118
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1469-74
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2027755-Actins,
pubmed-meshheading:2027755-Animals,
pubmed-meshheading:2027755-Base Sequence,
pubmed-meshheading:2027755-Blotting, Southern,
pubmed-meshheading:2027755-Cytosine,
pubmed-meshheading:2027755-DNA,
pubmed-meshheading:2027755-Dinucleoside Phosphates,
pubmed-meshheading:2027755-Drosophila,
pubmed-meshheading:2027755-Fishes,
pubmed-meshheading:2027755-Guanine,
pubmed-meshheading:2027755-Humans,
pubmed-meshheading:2027755-Metallothionein,
pubmed-meshheading:2027755-Methylation,
pubmed-meshheading:2027755-Molecular Sequence Data,
pubmed-meshheading:2027755-Rats
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pubmed:year |
1991
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pubmed:articleTitle |
Non-methylated islands in fish genomes are GC-poor.
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pubmed:affiliation |
Research Institute for Molecular Pathology, Vienna, Austria.
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pubmed:publicationType |
Journal Article
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