Linked Life Data

2027027

Source:http://linkedlifedata.com/resource/pubmed/id/2027027

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-6-7
pubmed:abstractText
We have used an immunocytochemical approach to investigate the inter-relationships between astrocytes, macrophages and microglia and the extracellular matrix components fibronectin and laminin, in 27 gliomas. Using recently available markers to macrophages and microglia (monoclonals Mac387, KP1 and the lectin RCA-1) and antisera to GFAP, fibronectin and laminin, we have described the reactions of these cells and the extracellular matrix. We found RCA-1 to be the superior marker for detecting most macrophages and microglia. There were more macrophages and microglia in high-grade gliomas than in low-grade. RCA-1 also reacted with endothelial cells in normal and reactive brain but showed markedly less affinity for endothelium in an close to gliomas. A possible role for the extracellular matrix in the astrocyte, macrophage and microglial reactions is discussed in the broader context of their role in the immune response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-510X
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-58
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Immunocytochemical study of macrophages and microglial cells and extracellular matrix components in human CNS disease. 1. Gliomas.
pubmed:affiliation
University Department of Neuropathology, University of Oxford, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't