|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
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|
pubmed:dateCreated |
1991-6-12
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|
pubmed:abstractText |
Avermectins with a wide range of novel C-25 substituents have been prepared by feeding carboxylic acids or their biosynthetic precursors to a Streptomyces avermitilis mutant strain ATCC 53568. This organism lacks the ability to form isobutyric and S-2-methylbutyric acids from their 2-oxo acid precursors and thus is unable to produce natural avermectins unless supplied with these acids. The novel avermectins produced by mutational biosynthesis possess broad-spectrum antiparasitic activity.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0021-8820
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
44
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
357-65
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pubmed:dateRevised |
2003-11-14
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|
pubmed:meshHeading |
pubmed-meshheading:2026561-Animals,
pubmed-meshheading:2026561-Anthelmintics,
pubmed-meshheading:2026561-Caenorhabditis,
pubmed-meshheading:2026561-Carboxylic Acids,
pubmed-meshheading:2026561-Chromatography, High Pressure Liquid,
pubmed-meshheading:2026561-Diptera,
pubmed-meshheading:2026561-Fermentation,
pubmed-meshheading:2026561-Ivermectin,
pubmed-meshheading:2026561-Molecular Structure,
pubmed-meshheading:2026561-Mutation,
pubmed-meshheading:2026561-Streptomyces
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|
pubmed:year |
1991
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|
pubmed:articleTitle |
Novel avermectins produced by mutational biosynthesis.
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|
pubmed:affiliation |
Central Research Division, Pfizer Ltd., Kent, England.
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pubmed:publicationType |
Journal Article
|
