Linked Life Data

2025146

Source:http://linkedlifedata.com/resource/pubmed/id/2025146

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1991-6-6
pubmed:abstractText
Hawaiian men of Japanese ancestry followed up for 18 or more years after a baseline examination showed a quadratic distribution of death rates at different levels of serum cholesterol. Mortality from cancer progressively decreased and mortality from coronary heart disease progressively increased with rising levels of serum cholesterol. There was a positive association between baseline serum cholesterol levels and deaths from coronary heart disease at 0 to 6 years, 7 to 12 years, and 13 years and longer after examination. The inverse relationship between cancer and serum cholesterol levels was stronger in the first 6 years than in the next 6 years and, although still inverse, lost statistical significance after 13 years. Cancers of the colon and lung showed the strongest association with low baseline serum cholesterol levels, while gastric or rectal cancer failed to show this association. Organ specificity and persistence of the inverse association beyond 6 years suggest that the nutritional demands of cancers may not entirely explain the inverse association with some cancers. The quadratic distribution of deaths in this cohort remained after coronary heart disease, stroke, and cancer were removed from the analysis. For the entire period of observation, the lowest mortalities were found in men with serum cholesterol levels between 4.65 and 6.18 mmol/L (between 180 and 239 mg/dL). Manipulation of serum cholesterol levels below this level would not be desirable if this were to result in increased risk of death from cancer or other disease. This study does not rule out this possibility.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0003-9926
pubmed:author
pubmed:issnType
Print
pubmed:volume
151
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
969-72
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Serum cholesterol and mortality among Japanese-American men. The Honolulu (Hawaii) Heart Program.
pubmed:affiliation
Japan-Hawaii Cancer Study, Honolulu 96817.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.